Melanogenesis Stimulation in Murine B16 Melanoma Cells by Piper nigrum Leaf Extract and Its Lignan Constituents
| Autor: | Yoshiko Kawaguchi, Michinori Kubo, Takayuki Kaihatsu, Yusuke Asanuma, Miho Yamazaki, Noriko Hirata, Shunsuke Naruto, Hideaki Matsuda |
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| Rok vydání: | 2004 |
| Předmět: |
Melanins
Pharmacology Lignan Piper Traditional medicine biology Plant Extracts Cell growth Melanoma Experimental Pharmaceutical Science Stimulation General Medicine Fractionation biology.organism_classification Lignans Plant Leaves Mice chemistry.chemical_compound Biochemistry chemistry Tumor Cells Cultured Animals Piper nigrum B16 melanoma Cell Proliferation |
| Zdroj: | Biological and Pharmaceutical Bulletin. 27:1611-1616 |
| ISSN: | 1347-5215 0918-6158 |
| DOI: | 10.1248/bpb.27.1611 |
| Popis: | A methanolic extract from the leaves of Piper nigrum L. showed a significant stimulatory effect on melanogenesis in cultured murine B16 melanoma cells. Activity-guided fractionation of the methanolic extract led to the isolation of two known lignans, (-)-cubebin (1) and (-)-3,4-dimethoxy-3,4-desmethylenedioxycubebin (2), together with a new lignan, (-)-3-desmethoxycubebinin (3). Among these lignans, 1 and 2 showed a significant stimulatory activity of melanogenesis without any significant effects on cell proliferation. |
| Databáze: | OpenAIRE |
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