Safety and efficacy of oral vinorelbine and capecitabine combination for metastatic breast cancer
| Autor: | Flavia Longo, M. Di Seri, Silvia Quadrini, R. De Sanctis, L. Stumbo, Paolo Grassi, E. Del Signore, Maria Luisa Basile, Daniela Adua, Bruno Gori |
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| Předmět: |
Adult
Male Oncology Antimetabolites Antineoplastic medicine.medical_specialty Anthracycline Administration Oral Breast Neoplasms Vinblastine Vinorelbine Deoxycytidine oral chemotherapy metastatic breast cancer capecitabine oral vinorelbine Capecitabine chemistry.chemical_compound Internal medicine Antineoplastic Combined Chemotherapy Protocols Humans Medicine Pharmacology (medical) Breast Aged Aged 80 and over Pharmacology Taxane business.industry Remission Induction Middle Aged medicine.disease Antineoplastic Agents Phytogenic Metastatic breast cancer Clinical trial Treatment Outcome Infectious Diseases chemistry Fluorouracil Disease Progression Female business medicine.drug |
| Zdroj: | Scopus-Elsevier Europe PubMed Central |
| Popis: | The aim of this prospective open-label study was to evaluate the efficacy and safety of oral vinorelbine in combination with capecitabine in patients with metastatic breast cancer (MBC). 51 patients with MBC received oral vinorelbine and capecitabine. The safety profile was analyzed through NCI-CTCAE v3.0 and response was evaluated using RECIST criteria. The overall response rate was 37.2%: there were four complete responders (8%) and fifteen partial responders (29.4%); practically all the responders were patients previously treated with anthracyclines and taxanes. Sixteen patients (31.3%) experienced stable disease. The clinical benefit rate was 68.5%. The median time to progression was 8 months (range 2-43; 95% CI: 6-10.8). Vinorelbine in combination with capecitabine is an effective and safe schedule for patients with MBC especially after pretreatment with anthracycline/ taxane-based regimens. The clinical benefit suggests that this may be a promising schedule in the MBC initial treatment. |
| Databáze: | OpenAIRE |
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