Lateral entorhinal cortex lesions impair both egocentric and allocentric object–place associations
| Autor: | David I. G. Wilson, Maneesh Varghese Kuruvilla, James A. Ainge |
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| Přispěvatelé: | BBSRC, University of St Andrews. Institute of Behavioural and Neural Sciences, University of St Andrews. School of Psychology and Neuroscience |
| Rok vydání: | 2020 |
| Předmět: |
0301 basic medicine
Dissociation (neuropsychology) NDAS Hippocampus medial entorhinal cortex 03 medical and health sciences Spatial memory 0302 clinical medicine associative navigation Association (psychology) Episodic memory Associative Landmark Cognitive map Landmarks General Neuroscience fungi Cognitive neuroscience of visual object recognition episodic memory spatial memory cognitive map Entorhinal cortex Navigation 030104 developmental biology landmarks RC0321 sense organs Neurology (clinical) Within and beyond the medial temporal lobe: brain circuits and mechanisms of recognition and place memory Psychology Medial entorhinal cortex RC0321 Neuroscience. Biological psychiatry. Neuropsychiatry Neuroscience 030217 neurology & neurosurgery Research Paper |
| Zdroj: | Brain and Neuroscience Advances |
| ISSN: | 2398-2128 |
| Popis: | This work was supported by Biotechnology and Biological Sciences Research Council (BBSRC) grant BB/I019367/1. During navigation, landmark processing is critical either for generating an allocentric-based cognitive map or in facilitating egocentric-based strategies. Increasing evidence from manipulation and single-unit recording studies has highlighted the role of the entorhinal cortex in processing landmarks. In particular, the lateral (LEC) and medial (MEC) sub-regions of the entorhinal cortex have been shown to attend to proximal and distal landmarks, respectively. Recent studies have identified a further dissociation in cue processing between the LEC and MEC based on spatial frames of reference. Neurons in the LEC preferentially encode egocentric cues while those in the MEC encode allocentric cues. In this study, we assessed the impact of disrupting the LEC on landmark-based spatial memory in both egocentric and allocentric reference frames. Animals that received excitotoxic lesions of the LEC were significantly impaired, relative to controls, on both egocentric and allocentric versions of an object–place association task. Notably, LEC lesioned animals performed at chance on the egocentric version but above chance on the allocentric version. There was no significant difference in performance between the two groups on an object recognition and spatial T-maze task. Taken together, these results indicate that the LEC plays a role in feature integration more broadly and in specifically processing spatial information within an egocentric reference frame. Publisher PDF |
| Databáze: | OpenAIRE |
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