Toxicity of 2,6-dichloro-1,4-benzoquinone and five regulated drinking water disinfection by-products for the Caenorhabditis elegans nematode
| Autor: | Ai-Lin Liu, Xue Han, Yu-Ting Zuo, Jing-Jing Cao, Wen-Qing Lu, Fan Wang, Yu Hu, Wei-Wei Lu |
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| Rok vydání: | 2016 |
| Předmět: |
0301 basic medicine
Environmental Engineering DNA damage Health Toxicology and Mutagenesis Dichloroacetic acid 010501 environmental sciences Biology 01 natural sciences Water Purification Toxicology Lethal Dose 50 03 medical and health sciences chemistry.chemical_compound Oxygen Consumption Benzoquinones Environmental Chemistry Bioassay Animals Trichloroacetic acid Caenorhabditis elegans Waste Management and Disposal 0105 earth and related environmental sciences EC50 Drinking Water biology.organism_classification Pollution Disinfection 030104 developmental biology Biochemistry chemistry Toxicity Biological Assay Respiration rate Water Pollutants Chemical DNA Damage Disinfectants |
| Zdroj: | Journal of hazardous materials. 321 |
| ISSN: | 1873-3336 |
| Popis: | Scarce toxicological data are available for 2,6-dichloro-1,4-benzoquinone (DCBQ), an emerging water disinfection by-product (DBP) that is of potential public health concern. This study investigated the effects of DCBQ on the lethality, respiration rate, and DNA damage in the Caenorhabditis elegans nematode. Meanwhile, the toxic effects of five regulated DBPs, dichloroacetic acid (DCA), trichloroacetic acid (TCA), monobromoacetic acid (MBA), dibromoacetic acid (DBA), and N-nitrosodimethylamine (NDMA), have also been evaluated. The tested DBPs increased the lethality and inhibited the respiration of C. elegans with an identical order of toxicity as follows: DCBQ>MBA>DBA>DCA>TCA>NDMA. The EC50 value (median concentration causing 50% reduction in respiration compared with untreated C. elegans) is at least 30-fold lower than the corresponding LC50 value (median lethal concentration). Exposure to DCBQ and NDMA, but not to MBA, DBA, DCA, or TCA, resulted in DNA damage to C. elegans. The study suggested that DCBQ was more potent in inducing general toxicity than some regulated DBPs, and it revealed the in vivo genotoxic effect of DCBQ. Furthermore, the C. elegans-based bioassays may provide potentially useful tools for the toxicology assessment and ranking of DBPs. |
| Databáze: | OpenAIRE |
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