Red cell distribution width (RDW) correlates with markers of diastolic dysfunction in patients with impaired left ventricular systolic function
| Autor: | Nashat Imran, Fadi Alattar, Saad Usmani, Fayez Shamoon, Pooja Patel |
|---|---|
| Rok vydání: | 2016 |
| Předmět: |
medicine.medical_specialty
medicine.medical_treatment Diastole 030204 cardiovascular system & hematology Asymptomatic Article 03 medical and health sciences 0302 clinical medicine Internal medicine RDW Medicine 030212 general & internal medicine Cardiac catheterization Left ventricular dysfunction business.industry Red blood cell distribution width medicine.disease Log-rank test Preload Heart failure Cardiology Ventricular pressure Diastolic dysfunction medicine.symptom Cardiology and Cardiovascular Medicine business |
| Zdroj: | International Journal of Cardiology. Heart & Vasculature |
| ISSN: | 2352-9067 |
| Popis: | Objective Red-cell distribution width (RDW) has been identified as a novel prognostic marker in a heterogeneous group of heart failure patients. In this group, diastolic dysfunction is associated with worse outcome. As the evidence is limited, the aim of the present study was to assess the relationship of RDW to diastolic markers in patients with left ventricular dysfunction (LVD) diagnosed during cardiac catheterization. Methods Clinical and angiographic data were collected retrospectively on a total of 291 stable patients (mean age 62 years, 199 males) with systolic dysfunction documented during cardiac catheterization in a regional medical center between January 2006 and December 2010. Results Positive association was seen between RDW and Left ventricular end diastolic pressure (LVEDP), estimated systolic pulmonary arterial pressure(sPAP), and left atrial dimension (LAD) (r: 0.18, 0.24, 0.28, respectively; p: 14.5) vs. normal RDW (73%vs.88%;log rank p:0.03). This was seen even in the asymptomatic subgroup (71% vs. 94%; log rank p: 0.01). Conclusion RDW correlates with markers of diastolic dysfunction in patients with LVD. Additionally, in patients asymptomatic LVD, high RDW is still associated with lower survival. |
| Databáze: | OpenAIRE |
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