Comparison of the nucleotide sequences of diabetogenic and nondiabetogenic encephalomyocarditis virus
| Autor: | Stuart H. Cohen, George W. Jordan, Robert K. Naviaux, Kurt M. Vanden Brink |
|---|---|
| Rok vydání: | 1988 |
| Předmět: |
chemistry.chemical_classification
Genetics Signal peptide Emc virus Base Sequence Molecular Sequence Data RNA Biology Virology Phenotype Virus Amino acid Diabetes Mellitus Experimental Mice chemistry Biological significance Sequence Homology Nucleic Acid Animals Nucleotide Amino Acid Sequence Encephalomyocarditis virus Peptide Hydrolases |
| Zdroj: | Virology. 166(2) |
| ISSN: | 0042-6822 |
| Popis: | The nucleotide sequences of a diabetogenic variant of encephalomyocarditis (EMC) virus (D variant, ifp − phenotype) and a nondiabetogenic variant of EMC virus (B variant, ifp + phenotype) have been compared. These variants differ at eight sites. The poly(C) tract of EMC-B is three bases shorter than that of EMC-D. Of the seven sites at which nucleotide substitutions were confirmed using RNA templates, four resulted in amino acid changes in three different proteins, the leader peptide, t B (VP2), and 1D (VPI ). The biological significance of these differences can now be investigated. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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