Difference in the brain serotonin and its metabolite level and anxiety-like behavior between forced and voluntary exercise conditions in rats
| Autor: | Daisuke Matsunaga, Takayuki Ishiwata, Hikaru Nakagawa |
|---|---|
| Rok vydání: | 2020 |
| Předmět: |
0301 basic medicine
Male medicine.medical_specialty Serotonin Metabolite Physical exercise Anxiety Motor Activity Serotonergic Amygdala Open field 03 medical and health sciences chemistry.chemical_compound 0302 clinical medicine Internal medicine Physical Conditioning Animal medicine Animals Rats Wistar business.industry General Neuroscience Brain Hydroxyindoleacetic Acid Rats 030104 developmental biology Endocrinology medicine.anatomical_structure chemistry Turnover Forced exercise business 030217 neurology & neurosurgery |
| Zdroj: | Neuroscience letters. 744 |
| ISSN: | 1872-7972 |
| Popis: | Physical exercise is beneficial to both physical and mental health, though it is unclear whether voluntary and forced exercise have the same effects. We investigated the effects of chronic forced and voluntary wheel running on brain levels of serotonin (5-HT), its metabolite 5-hydroxyindoleacetic acid (5-HIAA), and anxiety-like behavioral change in rats. Forty-eight rats were randomly assigned to standard cages (sedentary control: SC); voluntary exercise (free running on a wheel, V-EX); voluntary limited exercise (wheel available only 1 h per day, VL-EX); and forced exercise (running on a motorized wheel, F-EX). After 4 weeks, rats either underwent the open field test (OFT) or their 5-HT and 5-HIAA levels were measured in the major serotonergic neural cell bodies and projection areas. 5-HT and 5-HIAA levels in the dorsal and median raphe nuclei were increased in the V-EX, but not in the VL-EX and F-EX groups, compared with the SC group. In the paraventricular hypothalamic nucleus and caudate putamen, only 5-HT levels were increased in the V-EX group. Interestingly, in the amygdala, only 5-HIAA levels were significantly increased in the V-EX group. Conversely, we found that F-EX rats showed no significant 5-HT changes and increased anxiety-like behavior. VL-EX did not have significant beneficial effects on any of the experimental parameters. These data suggest that only unlimited voluntary exercise stimulates the serotonergic system and suppresses anxiety-like behavior. |
| Databáze: | OpenAIRE |
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