Estrogen Receptor Beta: The Promising Biomarker and Potential Target in Metastases
| Autor: | Vesna Mandusic, Ana Božović, Lidija Todorović, Milena Krajnović |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2021 |
| Předmět: |
Male
0301 basic medicine Carcinogenesis promoters Review Metastases medicine.disease_cause lcsh:Chemistry 0302 clinical medicine Prostate Endocrine-related cancers Neoplasm Metastasis lcsh:QH301-705.5 Spectroscopy Thyroid General Medicine tumor-suppressor 3. Good health Computer Science Applications Gene Expression Regulation Neoplastic Clinical Practice medicine.anatomical_structure 030220 oncology & carcinogenesis Biomarker (medicine) biomarker Female Promoters Colorectal Neoplasms carcinogenesis Tumor-suppressor Breast Neoplasms Methylation Catalysis Inorganic Chemistry 03 medical and health sciences Biomarkers Tumor medicine Humans Thyroid Neoplasms Physical and Theoretical Chemistry metastases Molecular Biology Estrogen receptor beta business.industry Organic Chemistry Estrogen Receptor alpha isoforms Prostatic Neoplasms Cancer Estrogen Receptor Beta Biomarker medicine.disease 030104 developmental biology Research knowledge lcsh:Biology (General) lcsh:QD1-999 Cancer research endocrine-related cancers methylation business Isoforms |
| Zdroj: | International Journal of Molecular Sciences International Journal of Molecular Sciences, Vol 22, Iss 1656, p 1656 (2021) |
| Popis: | The discovery of the Estrogen Receptor Beta (ERβ) in 1996 opened new perspectives in the diagnostics and therapy of different types of cancer. Here, we present a review of the present research knowledge about its role in endocrine-related cancers: breast, prostate, and thyroid, and colorectal cancers. We also discuss the reasons for the controversy of its role in carcinogenesis and why it is still not in use as a biomarker in clinical practice. Given that the diagnostics and therapy would benefit from the introduction of new biomarkers, we suggest ways to overcome the contradictions in elucidating the role of ERβ. Special Issue "Biomarkers in Hematological and Oncological Malignancies: Identification, Validation and Involvement in Molecular Pathways" |
| Databáze: | OpenAIRE |
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