A Novel Bone Resorption Inhibitor, A-75943 Isolated from Streptomyces sp. SANK 61296
| Autor: | Tomoko Ando, Morishita Tadaaki, Ryuzo Enokita, Takao Okazaki, Kiyoshi Oizumi, Aiya Sato, Masaaki Miyamoto |
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| Rok vydání: | 1998 |
| Předmět: |
Male
Spectrophotometry Infrared Stereochemistry In Vitro Techniques Cycloheximide Streptomyces Mass Spectrometry Bone resorption chemistry.chemical_compound Bone Density Drug Discovery Animals Bone Resorption Rats Wistar Pyrans Pharmacology biology Streptomycetaceae Biological activity biology.organism_classification Molecular biology In vitro Rats Resorption chemistry Fermentation Acetamide |
| Zdroj: | The Journal of Antibiotics. 51:531-538 |
| ISSN: | 1881-1469 0021-8820 |
| DOI: | 10.7164/antibiotics.51.531 |
| Popis: | A novel bone resorption inhibitor, A-75943, was isolated from Streptomyces sp. SANK 61296. Its structure was determined to be (1"S,2'R,3"S,4S',5"S)-2-[(3",5"- dimethyl-2"-oxocyclohexan-1"-yl)-6'-oxotetrahydropyran-4'-yl ]acetamide by spectral analyses and chemical conversion of cycloheximide. A-75943 inhibited bone resorption in vitro in a concentration-dependent manner with an IC50 of 0.35 microM, and also displayed an inhibitory effect on bone resorption in thyroid and parathyroid-extracted rats. |
| Databáze: | OpenAIRE |
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