High-sensitive C-reactive protein and risk of incident type 2 diabetes: a case–control study nested within the Singapore Chinese Health Study
| Autor: | Woon-Puay Koh, An Pan, Jian-Min Yuan, Yeli Wang |
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| Jazyk: | angličtina |
| Předmět: |
Male
medicine.medical_specialty China Endocrinology Diabetes and Metabolism 030209 endocrinology & metabolism Type 2 diabetes 030204 cardiovascular system & hematology C-reactive protein 03 medical and health sciences 0302 clinical medicine Internal medicine Diabetes mellitus medicine Confidence Intervals Odds Ratio Humans Prospective cohort study Aged 2. Zero hunger Inflammation biology business.industry Incidence Case-control study General Medicine Odds ratio Middle Aged medicine.disease 3. Good health Endocrinology Logistic Models Diabetes Mellitus Type 2 Case-Control Studies Cohort Multivariate Analysis biology.protein Female business Body mass index Prospective studies Biomarkers Research Article |
| Zdroj: | BMC Endocrine Disorders |
| ISSN: | 1472-6823 |
| DOI: | 10.1186/s12902-017-0159-5 |
| Popis: | Background The liver-derived C-reactive protein (CRP) is a sensitive and systemic biomarker of inflammation, and has been associated with increased risk of developing type 2 diabetes in populations other than Chinese. Therefore, we prospectively examined the relation between plasma levels of CRP and risk of type 2 diabetes (T2D) among a Chinese population. Methods Plasma high-sensitive CRP (hs-CRP) concentrations were assayed among 571 T2D cases and 571 controls nested in the prospective cohort of the Singapore Chinese Health Study. Both cases and controls were free of physician-diagnosed diabetes, cardiovascular disease and cancer at blood collections (1999–2004). Incident physician-diagnosed T2D cases were self-reported during the follow-up visits (2006–2010), and controls were matched for age (±3 years) and date (±6 months) of blood collection and gender. Multivariable logistic regression models were used to compute the odds ratio (OR) and the corresponding 95% confidence intervals (CIs). Results The mean (SD) concentrations of hs-CRP were 2.79 (2.65) and 1.86 (2.03) mg/L, respectively, in cases and controls (P |
| Databáze: | OpenAIRE |
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