Inversion of a chicken ets-1 proto-oncogene segment in avian leukemia virus E26
| Autor: | Takis S. Papas, J A Lautenberger |
|---|---|
| Rok vydání: | 1993 |
| Předmět: |
animal structures
Genes Viral viruses Molecular Sequence Data Retroviridae Proteins Oncogenic Immunology Microbiology Genome Virus Retrovirus Sequence Homology Nucleic Acid Virology Proto-Oncogenes RNA Messenger Gene Chromosomal inversion Genetics Rous sarcoma virus Avian Leukosis Virus Base Sequence biology biology.organism_classification Open reading frame Insect Science Coding strand Chromosome Inversion Research Article |
| Zdroj: | Journal of Virology. 67:610-612 |
| ISSN: | 1098-5514 0022-538X |
| DOI: | 10.1128/jvi.67.1.610-612.1993 |
| Popis: | The segment of the avian leukemia virus E26 genome near the termination of the p135gag-myb-ets open reading frame contains an inversion of the chicken ets-1 sequence. The inversion contains at least 41 bp and may be as large as 46 bp. This results in the replacement of 13 amino acids of chicken ets-1, with 16 amino acids derived from reverse complement of the normal ets-1 coding strand or read-through into E26 env sequences. At least 13 of these codons are specified by the inverted ets sequences. This represents the first reported occurrence of inverted oncogene sequences in a natural retrovirus. The inverted ets sequences are immediately followed by sequences homologous to the Rous sarcoma virus Prague B env gene. Since the E26 env sequence is more closely related to subgroup B avian retroviruses than to avian retroviruses from subgroups A, C, D, or E, the progenitor of E26 was a virus belonging to avian retrovirus subgroup B. |
| Databáze: | OpenAIRE |
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