Factors associated with the presentation of erosive esophagitis symptoms in health checkup subjects: A prospective, multicenter cohort study
Autor: | Hiromu Kutsumi, Masayasu Adachi, Tsuyoshi Fujita, Eiji Umegaki, Masaru Yoshida, Masao Kobayashi, Shuichi Terao, Naomi Mochizuki, Manabu Murakami, Tsuyoshi Sanuki, Akihiko Okada, Yoshifumi Arisaka, Takeshi Azuma, Atsuhiro Masuda, Yukinao Yamazaki, Koji Uno |
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Rok vydání: | 2018 |
Předmět: |
Male
Hernia NSAIDs Atrophic gastritis lcsh:Medicine Comorbidity Anxiety Pathology and Laboratory Medicine Gastroesophageal Reflux Disease Mathematical and Statistical Techniques 0302 clinical medicine Japan Sleep Initiation and Maintenance Disorders Surveys and Questionnaires Medicine and Health Sciences Prospective Studies lcsh:Science Prospective cohort study Analgesics Alcohol Consumption Multidisciplinary Depression Smoking Drugs Middle Aged Postprandial Period Pharmaceutical Preparations Gastritis 030220 oncology & carcinogenesis Physical Sciences Gastroesophageal Reflux Female 030211 gastroenterology & hepatology Esophagoscopy Symptom Assessment medicine.symptom Statistics (Mathematics) Research Article Cohort study Adult Gastritis Atrophic medicine.medical_specialty Alcohol Drinking Surgical and Invasive Medical Procedures Gastroenterology and Hepatology Research and Analysis Methods Asymptomatic Hiatal hernia 03 medical and health sciences Signs and Symptoms Rheumatology Diagnostic Medicine Internal medicine Laryngopharyngeal Reflux medicine Humans Kyphosis Obesity Statistical Methods Esophagitis Peptic Life Style Nutrition Pharmacology business.industry lcsh:R Biology and Life Sciences Heartburn Endoscopy medicine.disease Pain management Diet Hernia Hiatal Multivariate Analysis Asymptomatic Diseases lcsh:Q business Esophagitis Mathematics |
Zdroj: | PLoS ONE PLoS ONE, Vol 13, Iss 5, p e0196848 (2018) |
ISSN: | 1932-6203 |
Popis: | Background We aimed to clarify the factors associated with the presentation of erosive esophagitis (EE) symptoms in subjects undergoing health checkups. Methods We utilized baseline data from 7,552 subjects who underwent upper endoscopy for health screening in a prospective, multicenter cohort study. The subjects were asked to complete a questionnaire detailing their upper abdominal symptoms and lifestyle. Based on the heartburn and/or acid regurgitation frequency, the EE subjects were stratified into the following three groups: (1) at least one day a week (symptomatic EE [sEE]), (2) less than one day a week (mild symptomatic EE [msEE]), and (3) never (asymptomatic EE [aEE]). Postprandial distress syndrome (PDS) and epigastric pain syndrome (EPS) were defined according to the Rome III criteria. Results Of the 1,262 (16.7%) subjects (male 83.8%, mean age 52.6 years) with EE, the proportions of sEE, msEE and aEE were 15.0%, 37.2% and 47.9%, respectively. The sEE group showed significant associations with overlapping EPS (OR: 58.4, 95% CI: 25.2–160.0), overlapping PDS (OR: 9.96, 95% CI: 3.91–26.8), severe hiatal hernia (OR: 2.43, 95% CI: 1.43–4.05), experiencing high levels of stress (OR: 2.20, 95% CI: 1.43–3.40), atrophic gastritis (OR: 1.57, 95% CI: 1.03–2.36) and Los Angeles (LA) grade B or worse (OR: 1.72, 95% CI: 1.12–2.60) in the multivariate analysis. Conclusions Approximately one-sixth of EE subjects were symptomatic. A multifactorial etiology, including factors unrelated to gastric acid secretion, was associated with the symptom presentation of EE subjects. |
Databáze: | OpenAIRE |
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