Factors associated with the presentation of erosive esophagitis symptoms in health checkup subjects: A prospective, multicenter cohort study

Autor: Hiromu Kutsumi, Masayasu Adachi, Tsuyoshi Fujita, Eiji Umegaki, Masaru Yoshida, Masao Kobayashi, Shuichi Terao, Naomi Mochizuki, Manabu Murakami, Tsuyoshi Sanuki, Akihiko Okada, Yoshifumi Arisaka, Takeshi Azuma, Atsuhiro Masuda, Yukinao Yamazaki, Koji Uno
Rok vydání: 2018
Předmět:
Male
Hernia
NSAIDs
Atrophic gastritis
lcsh:Medicine
Comorbidity
Anxiety
Pathology and Laboratory Medicine
Gastroesophageal Reflux Disease
Mathematical and Statistical Techniques
0302 clinical medicine
Japan
Sleep Initiation and Maintenance Disorders
Surveys and Questionnaires
Medicine and Health Sciences
Prospective Studies
lcsh:Science
Prospective cohort study
Analgesics
Alcohol Consumption
Multidisciplinary
Depression
Smoking
Drugs
Middle Aged
Postprandial Period
Pharmaceutical Preparations
Gastritis
030220 oncology & carcinogenesis
Physical Sciences
Gastroesophageal Reflux
Female
030211 gastroenterology & hepatology
Esophagoscopy
Symptom Assessment
medicine.symptom
Statistics (Mathematics)
Research Article
Cohort study
Adult
Gastritis
Atrophic
medicine.medical_specialty
Alcohol Drinking
Surgical and Invasive Medical Procedures
Gastroenterology and Hepatology
Research and Analysis Methods
Asymptomatic
Hiatal hernia
03 medical and health sciences
Signs and Symptoms
Rheumatology
Diagnostic Medicine
Internal medicine
Laryngopharyngeal Reflux
medicine
Humans
Kyphosis
Obesity
Statistical Methods
Esophagitis
Peptic
Life Style
Nutrition
Pharmacology
business.industry
lcsh:R
Biology and Life Sciences
Heartburn
Endoscopy
medicine.disease
Pain management
Diet
Hernia
Hiatal
Multivariate Analysis
Asymptomatic Diseases
lcsh:Q
business
Esophagitis
Mathematics
Zdroj: PLoS ONE
PLoS ONE, Vol 13, Iss 5, p e0196848 (2018)
ISSN: 1932-6203
Popis: Background We aimed to clarify the factors associated with the presentation of erosive esophagitis (EE) symptoms in subjects undergoing health checkups. Methods We utilized baseline data from 7,552 subjects who underwent upper endoscopy for health screening in a prospective, multicenter cohort study. The subjects were asked to complete a questionnaire detailing their upper abdominal symptoms and lifestyle. Based on the heartburn and/or acid regurgitation frequency, the EE subjects were stratified into the following three groups: (1) at least one day a week (symptomatic EE [sEE]), (2) less than one day a week (mild symptomatic EE [msEE]), and (3) never (asymptomatic EE [aEE]). Postprandial distress syndrome (PDS) and epigastric pain syndrome (EPS) were defined according to the Rome III criteria. Results Of the 1,262 (16.7%) subjects (male 83.8%, mean age 52.6 years) with EE, the proportions of sEE, msEE and aEE were 15.0%, 37.2% and 47.9%, respectively. The sEE group showed significant associations with overlapping EPS (OR: 58.4, 95% CI: 25.2–160.0), overlapping PDS (OR: 9.96, 95% CI: 3.91–26.8), severe hiatal hernia (OR: 2.43, 95% CI: 1.43–4.05), experiencing high levels of stress (OR: 2.20, 95% CI: 1.43–3.40), atrophic gastritis (OR: 1.57, 95% CI: 1.03–2.36) and Los Angeles (LA) grade B or worse (OR: 1.72, 95% CI: 1.12–2.60) in the multivariate analysis. Conclusions Approximately one-sixth of EE subjects were symptomatic. A multifactorial etiology, including factors unrelated to gastric acid secretion, was associated with the symptom presentation of EE subjects.
Databáze: OpenAIRE
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