Organ-specific and systemic autoimmune diseases originate from defects in hematopoietic stem cells
| Autor: | F Takao, Muneo Inaba, Soe Than, Susumu Ikehara, Masayo Kawamura, Hiroko Hisha, Yukio Koide, R Yasumizu, T O Yoshida, Kikuya Sugiura |
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| Rok vydání: | 1990 |
| Předmět: |
Male
medicine.medical_specialty Lupus nephritis Fluorescent Antibody Technique Mice Inbred Strains medicine.disease_cause Autoimmune Diseases Diabetes Mellitus Experimental Autoimmunity Islets of Langerhans Mice Internal medicine Cyclosporin a medicine Animals Bone Marrow Transplantation Autoimmune disease Mice Inbred C3H Multidisciplinary business.industry H-2 Antigens Antibodies Monoclonal Hematopoietic Stem Cells medicine.disease Thrombocytopenic purpura Mice Mutant Strains Transplantation Endocrinology medicine.anatomical_structure Immunology Bone marrow business Insulitis Research Article |
| Zdroj: | Proceedings of the National Academy of Sciences. 87:8341-8344 |
| ISSN: | 1091-6490 0027-8424 |
| DOI: | 10.1073/pnas.87.21.8341 |
| Popis: | Transplantation of bone marrow cells from nonobese diabetic (NOD) mice, a model for type 1 diabetes mellitus, to C3H/HeN mice, which express I-E alpha molecules and have aspartic acid at residue 57 of the I-A beta chain, induced insulitis followed by overt diabetes in the recipient C3H/HeN mice more than 40 weeks after bone marrow transplantation. When cyclosporin A, which perturbs T-cell functions, was injected intraperitoneally into [NOD----C3H/HeN] chimeric mice daily for 1 month, the chimeric mice developed insulitis and overt diabetes within 20 weeks following bone marrow transplantation. Transplantation of bone marrow cells from (NZW x BXSB)F1 mice, which develop lupus nephritis, myocardial infarction, and idiopathic thrombocytopenic purpura, into C3H/HeN or C57BL/6J mice induced in the recipient strains both lupus nephritis and idiopathic thrombocytopenic purpura more than 3 months after transplantation. Transplantation of a stem-cell-enriched population from (NZW x BXSB)F1 mice into normal mice also induced autoimmune disease in the recipients. These results indicate that both systemic autoimmune disease and organ-specific autoimmune disease originate from defects that reside within the stem cells; the thymus and environmental factors such as sex hormones appear to act only as accelerating factors. |
| Databáze: | OpenAIRE |
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