Natural-based chiral task-specific deep eutectic solvents: a novel, effective tool for enantiodiscrimination in electroanalysis
| Autor: | Laura Micheli, Serena Arnaboldi, Patrizia R. Mussini, Mariangela Longhi, Simona Rizzo, Sara Grecchi, Andrea Mezzetta, Fabiana Arduini, Lorenzo Guazzelli, Elisa Emanuele |
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| Jazyk: | angličtina |
| Rok vydání: | 2021 |
| Předmět: |
General Chemical Engineering
Task-specific enantioselective media Salt (chemistry) 02 engineering and technology 010402 general chemistry 01 natural sciences chemistry.chemical_compound Settore CHIM/01 Electrochemistry Levulinic acid Chiral bio-based deep eutectic solvents Voltammetry Eutectic system chemistry.chemical_classification Enantiodiscrimination of electroactive probe enantiomers Chiral electroanalysis Chiral voltammetry on SPEs Enantioselective synthesis 021001 nanoscience & nanotechnology Combinatorial chemistry 0104 chemical sciences Enantiopure drug chemistry Ionic liquid Enantiomer 0210 nano-technology |
| Popis: | Deep Eutectic Solvents (DESs) offer advantages similar to ionic liquid (IL) ones, with easier and more sustainable synthesis; moreover, bio-based DESs often include chiral components, surprisingly underexploited. A proof of concept is now offered of the impressive potential of enantiopure chiral DESs as chiral media for enantioselective electroanalysis. Three chiral DESs, consisting of a molecular salt with bio-based chiral cation [NopolMIm]+ combined with three natural and/or low-cost partners (levulinic acid, glycerol and urea), are introduced and investigated as chiral voltammetry media. Significant potential differences are observed for the enantiomers of a model chiral probe, with a dramatic tuning depending on the achiral DES component, reaching an impressive ~0.5 V in the levulinic acid case (while less efficient appears [NopolMIm]+ as chiral additive in IL). With the same medium good enantiodiscrimination is also observed for aminoacid tryptophan, a quite different probe and of applicative interest. These findings can be considered as a remarkable step further in chiral electroanalysis as well as in the development of task-specific enantioselective media. |
| Databáze: | OpenAIRE |
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