Antimicrobial capacity of the freshwater planarians against S-aureus is under the control of Timeless
| Autor: | Benjamin Coiffard, Virginie Trouplin, Jean-Louis Mege, Gregory Gimenez, Cedric Torre, Eric Ghigo, Landry Laure Tsoumtsa |
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| Přispěvatelé: | Unité de Recherche sur les Maladies Infectieuses et Tropicales Emergentes (URMITE), Institut de Recherche pour le Développement (IRD)-Aix Marseille Université (AMU)-Institut National de la Santé et de la Recherche Médicale (INSERM)-IFR48, INSB-INSB-Centre National de la Recherche Scientifique (CNRS), Centre de Recherche en Cancérologie de Marseille (CRCM), Aix Marseille Université (AMU)-Institut Paoli-Calmettes, Fédération nationale des Centres de lutte contre le Cancer (FNCLCC)-Fédération nationale des Centres de lutte contre le Cancer (FNCLCC)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS), Centre d'Immunologie de Marseille - Luminy (CIML), Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS)-Aix Marseille Université (AMU), Max-Delbrück-Centrum für Molekulare Medizin in der Helmholtzgemeinschaft, 13125 Berlin, Germany, Institut des sciences biologiques (INSB-CNRS)-Institut des sciences biologiques (INSB-CNRS)-Centre National de la Recherche Scientifique (CNRS), Aix Marseille Université (AMU)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS), Max Delbrück Centrum für Molekulare Medizin (MDC) |
| Jazyk: | angličtina |
| Rok vydání: | 2017 |
| Předmět: |
0301 basic medicine
Microbiology (medical) Staphylococcus aureus Light Timeless Helminth protein Immunology medicine.disease_cause Microbiology 03 medical and health sciences Schmidtea mediterranea RNA interference [SDV.MHEP.MI]Life Sciences [q-bio]/Human health and pathology/Infectious diseases medicine Animals S aureus biology Helminth Proteins Period Circadian Proteins Tim biology.organism_classification 3. Good health CLOCK Editorial 030104 developmental biology Infectious Diseases Planarian Parasitology planarians MORN2 anti-bacterial response |
| Zdroj: | Virulence Virulence, Taylor & Francis, 2017, 8 (7), pp.1160-1169. ⟨10.1080/21505594.2016.1276689⟩ Virulence, 2017, 8 (7), pp.1160-1169. ⟨10.1080/21505594.2016.1276689⟩ |
| ISSN: | 2150-5594 2150-5608 |
| DOI: | 10.1080/21505594.2016.1276689⟩ |
| Popis: | International audience; Planarians, which are non-parasitic flatworms, are highly resistant to bacterial infections. To better understand the mechanisms underlying this resistance, we investigated the role of the circadian machinery in the anti-bacterial response of the freshwater planarian Schmidtea mediterranea. We identified Smed-Tim from S. mediterranea as a homolog of the mammalian clock gene Tim. We showed via RNA interference that Smed-Tim is required for the antimicrobial activities of Schmidtea mediterranea against Staphylococcus aureus infection during the light/dark cycle. Indeed, S. aureus infection leads to the expression of Smed-Tim, which in turn promotes Smed-Traf6 and Smed-morn2, but not Smed-p38 MAPK expression, 2 master regulators of planarian anti-microbial responses. |
| Databáze: | OpenAIRE |
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