Effect of sub-deficient zinc status on insulin sensitivity after burn injury in rats
| Autor: | Diane Agay, Laurence Touvard, Richard Claeyssen, M Andriollo-Sanchez, Josiane Arnaud, Antonia Alonso, Anne-Marie Roussel, Yves Chancerelle |
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| Přispěvatelé: | Laboratoire de bioénergétique fondamentale et appliquée (LBFA), Université Joseph Fourier - Grenoble 1 (UJF)-Institut National de la Santé et de la Recherche Médicale (INSERM), Centre de Recherches du Service de Santé des Armées (CRSSA), Service de Santé des Armées, Département de biologie intégrée, CHU Grenoble-Hôpital Michallon, Hamant, Sarah |
| Jazyk: | angličtina |
| Rok vydání: | 2009 |
| Předmět: |
Blood Glucose
Leptin Male MESH: Muscles Endocrinology Diabetes and Metabolism medicine.medical_treatment MESH: Random Allocation Clinical Biochemistry Biochemistry MESH: Zinc Antioxidants Random Allocation 0302 clinical medicine Insulin MESH: Animals Femur 2. Zero hunger 0303 health sciences Muscles General Medicine Protein catabolism Zinc MESH: Femur MESH: Insulin Resistance Liver Burns medicine.medical_specialty Normal diet MESH: Rats chemistry.chemical_element MESH: Insulin Inorganic Chemistry 03 medical and health sciences Insulin resistance MESH: Diet Internal medicine medicine [SDV.BBM] Life Sciences [q-bio]/Biochemistry Molecular Biology Weaning Animals [SDV.BBM]Life Sciences [q-bio]/Biochemistry Molecular Biology Rats Wistar 030304 developmental biology business.industry MESH: Burns Biochemistry (medical) MESH: Antioxidants 030208 emergency & critical care medicine MESH: Leptin MESH: Rats Wistar medicine.disease MESH: Male Diet Rats Disease Models Animal Endocrinology chemistry Zinc deficiency MESH: Blood Glucose Insulin Resistance MESH: Corticosterone MESH: Disease Models Animal business Corticosterone MESH: Liver |
| Zdroj: | Biological Trace Element Research Biological Trace Element Research, Humana Press, 2009, 127 (2), pp.132-42. ⟨10.1007/s12011-008-8226-4⟩ |
| ISSN: | 0163-4984 |
| DOI: | 10.1007/s12011-008-8226-4⟩ |
| Popis: | International audience; Although zinc status is an important parameter in insulin sensitivity, data concerning its implication in noxious burn-induced insulin resistance are scarce. The present study was designed to evaluate the impact of zinc status before burn on the recovery of injury with focus on plasma insulin and glucose levels. The experiment was performed in male adult Wistar rats fed from weaning with a zinc normal diet (80 ppm) or a depleted zinc diet (10 ppm) for 8 weeks and burned to third degree on 20% of their total body surface area. Blood and tissue samples were collected 3, 6, and 24 h after injury in order to study biochemical parameters and the glucose/insulin response in relation with the zinc status. After burn, zinc-depleted rats presented an exacerbated decrease in plasma zinc level. In addition, the burn-induced insulin resistance, leading to protein catabolism, was emphasized, with higher plasma insulin, glucose, and leptin levels in zinc-deficient animals versus normal-fed rats. Our experimental results underlined the interest to early control the zinc status in order to limit the deleterious effects of oxidative stress and insulin resistance in burned patients. |
| Databáze: | OpenAIRE |
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