Povezanost polimorfizma gena za interleukin-10 (-1082g/a) s tipom 2 šećerne bolesti i mikrovaskularnim komplikacijama u hrvatskoj populaciji
| Autor: | Jerko Barbić, Silvija Canecki-Varžić, Tamara Alkhamis, Ines Bilic-Curcic, Silvio Mihaljević, Jasenka Wagner, Ivana Škrlec, Ivana Prpić-Križevac |
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| Jazyk: | angličtina |
| Rok vydání: | 2018 |
| Předmět: |
medicine.medical_specialty
type 2 diabetes Infl ammation Interleukin-10 Single nucleotide polymorphism -1082G/A Microvascular complications Type 2 diabetes Inflammation Genotype Population lcsh:Medicine 030209 endocrinology & metabolism Polymorphism Single Nucleotide Diabetic nephropathy 03 medical and health sciences 0302 clinical medicine Gene Frequency Polymorphism (computer science) Internal medicine Diabetes mellitus medicine Humans Diabetic Nephropathies Obesity education Original Scientific Papers education.field_of_study business.industry lcsh:R General Medicine medicine.disease 3. Good health Endocrinology Diabetes Mellitus Type 2 Metabolic syndrome business Polyneuropathy 030217 neurology & neurosurgery Dijabetes tip 2 Upala SNP-1082G/A Mikrovaskularne komplikacije |
| Zdroj: | Acta Clinica Croatica, Vol 57., Iss 1. (2018) Acta clinica Croatica Volume 57. Issue 1. Acta Clinica Croatica |
| ISSN: | 1333-9451 0353-9466 |
| Popis: | Interleukin (IL)-10 is an anti-inflammatory cytokine, and a decrease in its secretion is associated with obesity, metabolic syndrome and type 2 diabetes. However, it has not been established whether the intensity of the immune response during diabetes-associated chronic inflammation affects the devel-opment and/or progression of type 2 diabetes and its microvascular complications. The aim of this study was to investigate the role of single nucleotide polymorphism (SNP)-1082G/A for IL-10 gene in development of diabetes type 2 and its complications. DNA was extracted from blood cells of 240 overweight/obese subjects for IL-10 genotyping. Based on the presence of diabetes type 2, patients were divided in two groups: experimental group of 144 patients with diabetes type 2 and control group of 96 age- and gender-matched subjects without diabetes. Compared to control group, diabetic group had higher levels of leukocytes (p=0.012), fibrinogen (p=0.049) and plasminogen activator inhibitor-1 (PAI-1) (p=0.009), and lower levels of albumin (p=0.001). There were no differences in the frequency of SNP-1082G/A for IL-10 gene between the two groups (p=0.654). When considering diabetes related traits in all subjects in relation to specific genotype, a group with homozygous (AA) genotype had higher values of the mean fasting glucose (p Smanjena sekrecija protuupalnog citokina interleukina (IL)-10 opisana je u debljini, metaboličkom sindromu i tipu 2 šećerne bolesti (T2ŠB). Međutim, nije utvrđeno može li intenzitet imunog odgovora tijekom kronične upale utjecati na razvoj i/ili progresiju dijabetesa kao i razvoj mikrovaskularnih komplikacija. Cilj ove studije bio je istražiti povezanost polimorfizma gena (SNP) -1082G/A za IL-10 s razvojem T2ŠB i kroničnih komplikacija. DNK za genotipizaciju se ekstrahirala iz krvnih stanica 240 adipoznih ispitanika koji su podijeljeni u dvije skupine: u eksperimentalnoj skupini bilo je 144 bolesnika s T2ŠB, a u kontrolnoj skupini 96 ispitanika usklađenih prema spolu i dobi. U skupini s T2ŠB nađene su više vrijednosti leukocita (p=0,012), fibrinogena (p=0,049) i inhibitora aktivacije plazminogena-1 (PAI-1) (p=0,009) te niže koncentracije albumina (p=0,001) nego u kontrolnoj skupini. Nije bilo statističke razlike u frekvencijama -1082G/A polimorfizma gena za IL-10 (p=0,654). Kada su se gledali ishodi za specifični genotip u svih ispitanika, ispitanici s homozigotnim genotipom (AA) imali su značajno više koncentracije glukoze natašte (p |
| Databáze: | OpenAIRE |
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