A perylene diimide zwitterionic polymer for photoacoustic imaging guided photothermal/photodynamic synergistic therapy with single near-infrared irradiation
| Autor: | Wenjun Wang, Weixing Deng, Xiaoxiao Wang, Rongcui Jiang, Pengfei Sun, Gaina Wang, Quli Fan, Qingming Shen, Wei Huang |
|---|---|
| Rok vydání: | 2018 |
| Předmět: |
inorganic chemicals
Materials science medicine.medical_treatment Biomedical Engineering Photodynamic therapy 02 engineering and technology 010402 general chemistry Photochemistry 01 natural sciences chemistry.chemical_compound Diimide medicine General Materials Science Irradiation chemistry.chemical_classification Atom-transfer radical-polymerization Singlet oxygen food and beverages General Chemistry General Medicine Polymer Photothermal therapy 021001 nanoscience & nanotechnology 0104 chemical sciences chemistry 0210 nano-technology Perylene |
| Zdroj: | Journal of Materials Chemistry B. 6:3395-3403 |
| ISSN: | 2050-7518 2050-750X |
| Popis: | Phototherapy has great promise for precise cancer diagnosis and effective therapy, but the development of one multifunctional nanoplatform for synergistic photodynamic therapy (PDT) and photothermal therapy (PTT) at a single excitation wavelength remains a challenge. In this work, a perylene diimide zwitterionic polymer PDS-PDI was synthesized via atom transfer radical polymerization (ATRP). This polymer was designed for photoacoustic imaging (PAI) guided synergistic PDT and PTT with single 660 nm near-infrared (NIR) light irradiation. The prepared PDS-PDI polymer presents high photothermal conversion efficiency (η≈ 40%) and efficient singlet oxygen quantum yield (ΦΔ≈ 16.7%) under 660 nm laser irradiation. Polymer PDS-PDI also acts as a contrast agent for PAI, offering real-time monitoring in tumor sites. Additionally, in vitro and in vivo assays indicate that polymer PDS-PDI has good biocompatibility and effective tumor destruction ability under 660 nm laser irradiation. In brief, polymer PDS-PDI prepared in this study could be applied as a dual-mode phototherapeutic agent under single laser irradiation. |
| Databáze: | OpenAIRE |
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