Impact of a Pre-Operative Exercise Intervention on Breast Cancer Proliferation and Gene Expression: Results from the Pre-Operative Health and Body (PreHAB) Study
| Autor: | Deborah A. Dillon, Sara M. Tolaney, Matthew Pun, Eric P. Winer, Esther Rhei, Melinda L. Irwin, Rachel A. Freedman, Elizabeth S. Frank, Anita Giobbie-Hurder, Krishan Taneja, Ryan J.O. Dowling, Laura S. Dominici, Myles Brown, Nancy Campbell, Jennifer A. Ligibel, Rinath Jeselsohn, Anne McTiernan, Ying Huang, Rachel L. Yung, MacIntosh Cornwell, Mehra Golshan, Martin C. Chang, Anees B. Chagpar |
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| Rok vydání: | 2019 |
| Předmět: |
0301 basic medicine
Cancer Research medicine.medical_specialty Breast Neoplasms Newly diagnosed Preoperative care 03 medical and health sciences 0302 clinical medicine Breast cancer Internal medicine Preoperative Care medicine Humans Exercise Cell Proliferation Exercise intervention business.industry Exercise therapy Mean age medicine.disease Pre operative Exercise Therapy 030104 developmental biology Oncology 030220 oncology & carcinogenesis Female business Body mass index |
| Zdroj: | Clinical Cancer Research. 25:5398-5406 |
| ISSN: | 1557-3265 1078-0432 |
| DOI: | 10.1158/1078-0432.ccr-18-3143 |
| Popis: | Purpose: Exercise after breast cancer diagnosis is associated with lower cancer-specific mortality, but the biological mechanisms through which exercise impacts breast cancer are not fully understood. The Pre-Operative Health and Body (PreHAB) Study was a randomized window-of-opportunity trial designed to test the impact of exercise on Ki-67, gene expression, and other biomarkers in women with breast cancer. Experimental Design: Inactive women with newly diagnosed breast cancer were randomized to an exercise intervention or mind–body control group, and participated in the study between enrollment and surgery (mean 29.3 days). Tumor and serum were collected at baseline and surgery. Results: Forty-nine women were randomized (27 exercise, 22 control). At baseline, mean age was 52.6, body mass index was 30.2 kg/m2, and exercise was 49 minutes/week. Exercise participants significantly increased exercise versus controls (203 vs. 23 minutes/week, P < 0.0001). There were no differences in changes of expression of Ki-67, insulin receptor, and cleaved caspase-3 in exercise participants versus controls. KEGG pathway analysis demonstrated significant upregulation of 18 unique pathways between the baseline biopsy and surgical excision in exercise participants and none in control participants (q < 0.1). Top-ranked pathways included several implicated in immunity and inflammation. Exploratory analysis of tumor immune infiltrates demonstrated a trend toward a decrease in FOXP3+ cells in exercise versus control participants over the intervention period (P = 0.08). Conclusions: A window-of-opportunity exercise intervention did not impact proliferation but led to alterations in gene expression in breast tumors, suggesting that exercise may have a direct effect on breast cancer. See related commentary by Koelwyn and Jones, p. 5179 |
| Databáze: | OpenAIRE |
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