COMPARISON OF 4 PROLIFERATION MARKERS AND THEIR SIGNIFICANCE FOR EVALUATION OF TUMOR DIGNITY IN INTRACRANIAL TUMORS

Autor:	Dk Stavrou, Christian Hagel, P Schwartz, Rudolf Laas
Rok vydání:	1995
Předmět:	Cancer Research Pathology medicine.medical_specialty Proliferation index Oncogene biology Cell cycle Proliferating cell nuclear antigen chemistry.chemical_compound Oncology chemistry Antigen medicine biology.protein neoplasms Grading (tumors) Bromodeoxyuridine High-power field
Zdroj:	International Journal of Oncology.
ISSN:	1791-2423 1019-6439
DOI:	10.3892/ijo.7.1.107
Popis:	The proliferation indices of immunohistochemically detected bromodeoxyuridine, Ki-67 antigen (antibodies Ki-67 and MIB 1), and proliferating cell nuclear antigen were determined manually and with computer assisted morphometry in 38 gliomas, 29 meningeomas, 9 metastases, and 16 other tumors. Comparing the markers among one another the highest correlation coefficient was found for bromodeoxyuridine and MIB 1 (0.9). The proliferation indices of all markers correlated significantly with the tumor grading. The highest correlation coefficient for proliferation index and grading (0.7) was calculated for the MIB 1 index determined in one high power field (0.0153 mm(2)) in the tissue area with the highest proliferative activity. Concerning applicability and correlation with tumor dignity MIB 1 was superior to the other three antibodies investigated.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3ddfa7512bbdbe3bec9b63b079fab743 https://doi.org/10.3892/ijo.7.1.107 Zobrazit plný text záznamu