Significance of Free to Total PSA Ratio in Men with Slightly Elevated Serum PSA Levels: A Cooperative Study
| Autor: | Yoichi Arai, Shin Egawa, Hidetoshi Yamanaka, Kyoichi Imai, Manabu Kuriyama, Ken Koshiba, Yukimichi Kawada, Hiroshi Maeda |
|---|---|
| Rok vydání: | 1998 |
| Předmět: |
Male
Gynecology Cancer Research medicine.medical_specialty business.industry Free psa Urology Prostatic Neoplasms Cancer Diagnostic accuracy General Medicine Prostate-Specific Antigen medicine.disease Sensitivity and Specificity Elevated serum Prostate-specific antigen Prostate cancer Oncology medicine Humans Radiology Nuclear Medicine and imaging Clinical significance business Total psa |
| Zdroj: | Japanese Journal of Clinical Oncology. 28:661-665 |
| ISSN: | 1465-3621 0368-2811 |
| DOI: | 10.1093/jjco/28.11.661 |
| Popis: | Background: The ratio of free PSAin total PSA(fit) has been reported to improve the diagnostic accuracy of prostate cancer in the groupwith slightly elevated serum PSA values. In Japanese cases, the clinical significance of fit is still controversial. Methods: The diagnostic significance of fit in serum for prostate cancer was evaluated in a cooperative study. A total of 77 cases with prostate cancer and 224 with non-prostate cancer showing less than 20 ng/ml of total PSAwere evaluated. Results: Serum total and free PSA values were not affected by storage at 25°C for 2 days. The determination of fit was useful in the cases with a serum total PSA of 5.1-10 ng/ml; the specificity was 60% with a sensitivity of 90% at an fit of 0.148. The positive predictive value for diagnosis of prostate cancer also increased to 54%from 34% of that in total PSA alone. In the range of 4.1-10 ng/ml, the cut-off value of fit was 0.155 for obtaining relatively high specificity; sensitivity was 85% and specificity was 56.5%. Conclusions: Thus, thedetermination offit wasconsidered to beaneffective tool fordiscriminating the non-prostate cancer cases from those of prostate cancer. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|