Operation of mitochondrial machinery in viral infection-induced immune responses

Autor: Shue-Fen Luo, Jenn-Haung Lai, Ling-Jun Ho
Rok vydání: 2018
Předmět:
0301 basic medicine
PRR
pattern recognition receptor
DENV
dengue virus
cGAS
cyclic GMP–AMP synthase
Mitochondrion
Mitochondrial Dynamics
Biochemistry
NLR
NOD-like receptor
Mfn
mitofusin
Mitophagy
TRAF
TNF receptor-associated factor
RIPK2
cytosolic receptor interacting serine/threonine kinase 2
SARS-CoV
severe acute respiratory syndrome-coronavirus
NLRP3
NOD-
LRR- and pyrin domain-containing 3
Mitochondria
Virus
Cell biology
CLR
C-type lectin receptor
TNFα
tumor necrosis factor α
OPA1
optic atrophy 1
Virus Diseases
CARD
caspase activation and recruitment domain
HCV
hepatitis C virus
MAVS
mitochondrial antiviral signaling protein
HPIV3
human parainfluenza virus type 3
PAMP
pathogen-associated molecular pattern
DAMP
danger-associated molecular pattern
Mitochondrial DNA
JEV
Japanese encephalitis virus
PINK1
phosphatase and tensin homolog (PTEN)-induced kinase 1
STING
stimulator of interferon genes
Biology
Antiviral Agents
Article
03 medical and health sciences
NF-κB
nuclear factor-kappaB
ROS
reactive oxygen species
Immune system
ORF
open reading frame
Downregulation and upregulation
Immunity
KSHV
kaposi’s sarcoma-associated herpesvirus
Animals
Humans
IFN
interferon
TLR
toll-like receptor
ComputingMethodologies_COMPUTERGRAPHICS
Pharmacology
Immunity
Innate
RLR
retinoic acid-inducible gene 1-like receptor
mtDNA
mitochondrial DNA
vMIA
viral mitochondrion-localized inhibitor of apoptosis
Immune
RIG-I
retinoic acid-inducible gene 1
Drp 1
dynamin-related protein 1
030104 developmental biology
Apoptosis
CO
cytochrome C oxidase
RSV
respiratory syncytial virus
Therapy
MAPK
mitogen-activated protein kinase
IRF
interferon regulatory factor
Zdroj: Biochemical Pharmacology
ISSN: 0006-2952
DOI: 10.1016/j.bcp.2018.08.044
Popis: Graphical abstract
Mitochondria have been recognized as ancient bacteria that contain evolutionary endosymbionts. Metabolic pathways and inflammatory signals interact within mitochondria in response to different stresses, such as viral infections. In this commentary, we address several interesting questions, including (1) how do mitochondrial machineries participate in immune responses; (2) how do mitochondria mediate antiviral immunity; (3) what mechanisms involved in mitochondrial machinery, including the downregulation of mitochondrial DNA (mtDNA), disturbances of mitochondrial dynamics, and the induction of mitophagy and regulation of apoptosis, have been adopted by viruses to evade antiviral immunity; (4) what mechanisms involve the regulation of mitochondrial machineries in antiviral therapeutics; and (5) what are the potential challenges and perspectives in developing mitochondria-targeting antiviral treatments? This commentary provides a comprehensive review of the roles and mechanisms of mitochondrial machineries in immunity, viral infections and related antiviral therapeutics.
Databáze: OpenAIRE
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