An assessment of potential biomarkers of environment enteropathy and its association with age and microbial infections among children in Bangladesh

Autor: Regina C. LaRocque, Shahidul Islam, Edward T. Ryan, Daniel T. Leung, Naoshin Sharmin Nishat, Aklima Akter, Motaher Hossain, Muhammad Ikhtear Uddin, Taufiqur Rahman Bhuiyan, Jason B. Harris, Firdausi Qadri, Tanzeem Ahmed Rafique, Tasnin Akter Nila, Stephen B. Calderwood
Jazyk: angličtina
Rok vydání: 2021
Předmět:
Male
Gastrointestinal Diseases
Lipopolysaccharide Receptors
Toxicology
Pathology and Laboratory Medicine
Gastroenterology
Biochemistry
Cohort Studies
Feces
Medical Conditions
Medicine and Health Sciences
Toxins
Cumulative incidence
Enteropathy
Gastrointestinal tract
Multidisciplinary
biology
Diarrhea
Research Design
Virus Diseases
Myeloperoxidase
Child
Preschool
Medicine
Female
medicine.symptom
Antibody
Anatomy
Research Article
medicine.medical_specialty
Science
Toxic Agents
Bacterial Toxins
Nutritional Status
Gastroenterology and Hepatology
Research and Analysis Methods
Microbiology
Antibodies
Signs and Symptoms
Internal medicine
Virology
medicine
Parasitic Diseases
Humans
Nutrition
Peroxidase
business.industry
Infant
Newborn
Biology and Life Sciences
Infant
medicine.disease
Endotoxins
Gastrointestinal Tract
Malnutrition
biology.protein
Clinical Medicine
business
Digestive System
Biomarkers
Viral Transmission and Infection
Zdroj: PLoS ONE
PLoS ONE, Vol 16, Iss 4, p e0250446 (2021)
ISSN: 1932-6203
Popis: Interventional studies targeting environment enteropathy (EE) are impeded by the lack of appropriate, validated, non-invasive biomarkers of EE. Thus, we aimed to validate the association of potential biomarkers for EE with enteric infections and nutritional status in a longitudinal birth cohort study. We measured endotoxin core antibody (EndoCab) and soluble CD14 (sCD14) in serum, and myeloperoxidase (MPO) in feces using commercially available enzyme-linked immunosorbent assay (ELISA) kits. We found that levels of serum EndoCab and sCD14 increase with the cumulative incidence of enteric infections. We observed a significant correlation between the fecal MPO level in the children at 24 months of age with the total number of bacterial and viral infections, the total number of parasitic infections, and the total number of diarrheal episodes and diarrheal duration. We observed that the levels of serum EndoCab, sCD14, and fecal MPO at 3 months of age were significantly associated with whether children were malnourished at 18 months of age or not. Biomarkers such as fecal MPO, serum EndoCab and sCD14 in children at an early age may be useful as a measure of cumulative burden of preceding enteric infections, which are predictive of subsequent malnutrition status and may be useful non-invasive biomarkers for EE.
Databáze: OpenAIRE
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