Genome of the Komodo dragon reveals adaptations in the cardiovascular and chemosensory systems of monitor lizards
Autor: | Pui-Yan Kwok, Elio Schijlen, James W. Hicks, Katherine S. Pollard, Marie Altmanová, Alex I. Makunin, Tomaso Patarnello, Petr Velenský, Michail Rovatsos, Yulia Mostovoy, Alisha K. Holloway, Vladimir A. Trifonov, Valerio Orlandini, Yvonne Y. Y. Lai, Marco Fondi, Massimo Milan, Ivan Rehák, Renato Fani, I. G. Kichigin, Lukáš Kratochvíl, Benoit G. Bruneau, Alessio Iannucci, Claudio Ciofi, Martina Johnson Pokorná, Tim S. Jessop, Oliver A. Ryder, Walter L. Eckalbar, Angel C.Y. Mak, Abigail L. Lind, Joseph R. Mendelson |
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Rok vydání: | 2019 |
Předmět: |
0106 biological sciences
0301 basic medicine Komodo dragon Varanus komodoensis Genome Acclimatization 1.1 Normal biological development and functioning Sequence assembly Cardiovascular Cardiovascular System 010603 evolutionary biology 01 natural sciences Genome Animals Chromosomes Lizards Article BIOS Applied Bioinformatics 03 medical and health sciences Drug Delivery Systems Underpinning research biology.animal Genetics Life Science Gene Ecology Evolution Behavior and Systematics Monitor lizard Ecology biology Lizard Human Genome DNA biology.organism_classification 030104 developmental biology Evolutionary biology Ectotherm Komodo dragon Adaptation |
Zdroj: | Nature ecology & evolution, vol 3, iss 8 Nature ecology & evolution Nature Ecology and Evolution 3 (2019) 8 Nature Ecology and Evolution, 3(8), 1241-1252 |
ISSN: | 2397-334X |
Popis: | Monitor lizards are unique among ectothermic reptiles in that they have high aerobic capacity and distinctive cardiovascular physiology resembling that of endothermic mammals. Here, we sequence the genome of the Komodo dragon Varanus komodoensis, the largest extant monitor lizard, and generate a high-resolution de novo chromosome-assigned genome assembly for V. komodoensis using a hybrid approach of long-range sequencing and single-molecule optical mapping. Comparing the genome of V. komodoensis with those of related species, we find evidence of positive selection in pathways related to energy metabolism, cardiovascular homoeostasis, and haemostasis. We also show species-specific expansions of a chemoreceptor gene family related to pheromone and kairomone sensing in V. komodoensis and other lizard lineages. Together, these evolutionary signatures of adaptation reveal the genetic underpinnings of the unique Komodo dragon sensory and cardiovascular systems, and suggest that selective pressure altered haemostasis genes to help Komodo dragons evade the anticoagulant effects of their own saliva. The Komodo dragon genome is an important resource for understanding the biology of monitor lizards and reptiles worldwide. |
Databáze: | OpenAIRE |
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