Salvage treatment in male patients with germ cell tumours
| Autor: | A. E. Stenwig, Sophie D. Fosså, S. Ous, Dag Josefsen, Johan Høie |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 1993 |
| Předmět: |
Adult
Male Cancer Research medicine.medical_specialty Adolescent medicine.medical_treatment Salvage therapy Malignancy chemistry.chemical_compound Testicular Neoplasms Recurrence Antineoplastic Combined Chemotherapy Protocols medicine Humans Radical surgery Aged Retrospective Studies Salvage Therapy Chemotherapy business.industry Remission Induction Middle Aged Neoplasms Germ Cell and Embryonal medicine.disease Carboplatin Discontinuation Surgery Radiation therapy Oncology chemistry business Brain metastasis Research Article |
| Zdroj: | British Journal of Cancer |
| ISSN: | 1532-1827 0007-0920 |
| Popis: | The outcome of salvage treatment was reviewed in 55 patients relapsing during or after their primary chemotherapy for advanced malignant germ cell tumours. Fifty-two patients had been given cisplatin-based chemotherapy as their primary treatment, whereas three patients had received carboplatin-based chemotherapy. The median time to relapse was 2 months (range: 0-96 months) from discontinuation of the primary treatment. Two patients underwent radical surgery only, and one patient had radiotherapy to a brain metastasis as his only curatively intended salvage treatment. Six patients did not receive any treatment for their recurrent malignancy (refusal, terminal condition) except for purely palliative measures. The disease-free survival for the total group was 27% at 5 years. Complete response to primary treatment lasting for > or = 6 months was the only parameter which significantly predicted a favourable outcome (45% 5 year disease-free survival in 12 eligible patients). |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|