Recurrent amelanotic melanoma of nasal cavity: Biological variability and unpredictable behavior of mucosal melanoma. A case report
| Autor: | Nives Jonjić, Dag Zahirović, Ingrid Belac-Lovasić, Damir Vučinić, Leo Kovač, Tamara Braut, Gordana Zamolo, Dubravko Manestar |
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| Jazyk: | angličtina |
| Rok vydání: | 2019 |
| Předmět: |
Nasal cavity
Amelanotic melanoma medicine.medical_specialty BIOMEDICINE AND HEALTHCARE. Clinical Medical Sciences medicine.medical_treatment Mucous membrane of nose Case Report Pembrolizumab 03 medical and health sciences 0302 clinical medicine Biopsy medicine Amelanotic melanoma Nasal cavity Mucosal melanoma Immunotherapy Radiotherapy 030223 otorhinolaryngology lcsh:R5-920 medicine.diagnostic_test Radiotherapy business.industry BIOMEDICINA I ZDRAVSTVO. Kliničke medicinske znanosti Mucosal melanoma General Medicine medicine.disease Radiation therapy medicine.anatomical_structure 030220 oncology & carcinogenesis Radiology Immunotherapy business lcsh:Medicine (General) Rhinoscopy |
| Zdroj: | Clinics and Practice, Vol 9, Iss 2 (2019) Clinics and Practice Volume 9 Issue 2 |
| ISSN: | 2039-7283 2039-7275 |
| Popis: | The aim of this report is to present a case of a patient with a recurrent nasal cavity amelanotic melanoma (AM), with emphasis on diagnosis and therapy options of this clinical entity. A 65-year-old female patient presented with pain in the right cheek region and nasal obstruction. In 2013, she was diagnosed with mucosal melanoma (MM) of the left nasal cavity. After endoscopic surgery and radiotherapy, the patient was followed by the oncology team. Five years after the initial diagnosis, rhinoscopy showed a tumorous formation in the right nasal cavity. The tumor mass was without black discoloration and was the same color as the surrounding nasal mucosa. Microscopic examination after biopsy of the tumor confirmed amelanotic MM. The patient underwent an additional endoscopic surgery. A complete standard diagnostic workup for MM found metastases in head and neck lymph nodes, on both sides. MMs of head and neck are uncommon malignancies. Unique biology of MM cells causes a high rate of recurrences. This report presents an example of recurrent AM of the nasal cavity, in treatment with checkpoint inhibitor (pembrolizumab), which could provide a good therapy option for patients with MM. |
| Databáze: | OpenAIRE |
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