Does a pleiotropic gene explain deafness and blue irises in white cats?
| Autor: | Claude Gaillard, Silvia Heid, Kristen Danielson, Frank Steffen, Caroline Geigy, André Jaggy |
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| Rok vydání: | 2007 |
| Předmět: |
Male
Deafness Biology Cat Diseases Gene Frequency Evoked Potentials Auditory Brain Stem otorhinolaryngologic diseases Animals Hair Color Allele frequency Gene Genetics Likelihood Functions CATS Eye Color General Veterinary Heritability Major gene Pedigree Iris colour White (mutation) Acoustic Stimulation Dominant white Cats Female Animal Science and Zoology |
| Zdroj: | The Veterinary Journal. 173:548-553 |
| ISSN: | 1090-0233 |
| DOI: | 10.1016/j.tvjl.2006.07.021 |
| Popis: | The prevalence of deafness is high in cat populations in which the dominant white gene is segregating. The objective of this study was to investigate whether there is a gene that is responsible for deafness as well as for blue eyes and to establish a plausible mode of inheritance. For this purpose, data from an experimental colony with deaf cats were analyzed. The hearing status was determined by acoustically evoked brain stem responses (BAER). Complex segregation analyses were conducted to find out the most probable mode of inheritance using maximum likelihood procedures. The prevalence of deafness and partial hearing in the experimental colony was 67% and 29%, respectively. The results of the bivariate segregation analysis support the hypothesis of a pleiotropic major gene segregating for deafness and blue iris colour. The high heritability coefficients for both traits, 0.55 and 0.75 respectively, indicate that beside the major gene there is an important influence of polygenic effects. |
| Databáze: | OpenAIRE |
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