Experimental respiratory syncytial virus infection of four species of primates
| Autor: | W. T. London, D. A. Prevar, Ena Camargo, D L Sly, R M Chanock, Lorfeld Jh, R. B. Belshe, Linda S. Richardson |
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| Rok vydání: | 1977 |
| Předmět: |
Pan troglodytes
viruses Biology Antibodies Viral Virus Species Specificity Neutralization Tests Virology Immunopathology Nasopharynx Animals Respiratory Tract Infections Saimiri Plaque-forming unit Respiratory tract infections Respiratory infection Haplorhini biology.organism_classification Macaca mulatta Attenuated Live Virus Vaccine Respiratory Syncytial Viruses Titer Disease Models Animal Infectious Diseases |
| Zdroj: | Journal of medical virology. 1(3) |
| ISSN: | 0146-6615 |
| Popis: | Four species of nonhuman primates were inoculated intranasally with 10(3.1) to 10(3.7) plaque forming units (pfu) of respiratory syncytial (RS) virus. Adults squirrel monkeys and newborn rhesus monkeys became infected and shed small quantities (peak titer 10(2.0) pfu/ml of nasopharyngeal swab specimen) of virus, but illness did not develop. Infant cebus monkeys aged 2 months became infected, shed 10(2.3) to 10(3.8) pfu/ml of nasopharyngeal swab specimen, but did not become ill. Chimpanzees aged 15 to 18 months shed a large quantity of virus, up to 10(6.0) pfu/ml of nasopharyngeal swab specimen and developed an upper respiratory illness. Chimpanzees are proposed as a possible animal model for future study of the immunopathology of RS virus disease and for in vivo evaluation of attenuated live virus vaccine candidates. |
| Databáze: | OpenAIRE |
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