Warfarin-induced changes in procoagulant and anticoagulant proteins
| Autor: | Stirling Y |
|---|---|
| Rok vydání: | 1995 |
| Předmět: |
medicine.medical_specialty
Vitamin K medicine.drug_class medicine.medical_treatment Protein S chemistry.chemical_compound Coumarins Internal medicine Vitamin K deficiency medicine Animals Humans Hemostasis Chemotherapy business.industry Anticoagulant Antagonist Warfarin Anticoagulants Hematology General Medicine Vitamin K antagonist Dicoumarol medicine.disease Coumarin Blood Coagulation Factors Endocrinology chemistry Vitamin K Deficiency business Protein C medicine.drug |
| Zdroj: | Blood Coagulation & Fibrinolysis. 6:361-373 |
| ISSN: | 0957-5235 |
| DOI: | 10.1097/00001721-199507000-00001 |
| Popis: | Dicoumarol was found to be the causative agent of a haemorrhagic disease in cattle following the ingestion of spoiled sweet clover. Vitamin K deficiency in chickens caused bleeding. Dicoumarol was later determined to be a vitamin K antagonist. A more potent form of the drug was produced synthetically and, following its initial use as rat poison, was recognized as a potential anti-thrombotic treatment in humans. The mode of action of a coumarin derivative (i.e. warfarin) is described. The overall effect of high-dose and low-dose warfarin and the possibility of a transient state of hypercoagulability on the introduction and withdrawal of treatment is considered. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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