NOD2 Genotypes Affect the Symptoms and Mortality in the Porcine Circovirus 2-Spreading Pig Population
| Autor: | Haruki Kitazawa, Gou Yoshioka, Toshimi Matsumoto, Kasumi Suzuki, Junji Tanaka, Hirohide Uenishi, Noboru Hayashi, Hiroki Shinkai |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2021 |
| Předmět: |
Circovirus
Male disease resistance Genotype Population Nod2 Signaling Adaptor Protein Biology QH426-470 Polymorphism Single Nucleotide Article Microbiology chemistry.chemical_compound NOD2 Genetics Animals Genetic Predisposition to Disease post-weaning multisystemic wasting syndrome Allele Circoviridae Infections education Allele frequency Genetics (clinical) Phylogeny Swine Diseases education.field_of_study Pattern recognition receptor pattern recognition receptors swine biology.organism_classification digestive system diseases PCV2 Porcine circovirus chemistry Host-Pathogen Interactions Capsid Proteins Female Peptidoglycan |
| Zdroj: | Genes, Vol 12, Iss 1424, p 1424 (2021) Genes Volume 12 Issue 9 |
| ISSN: | 2073-4425 |
| Popis: | The nucleotide oligomerization domain (NOD)-like receptor 2 (NOD2) is an intracellular pattern recognition receptor that detects components of peptidoglycans from bacterial cell walls. NOD2 regulates bowel microorganisms, provides resistance against infections such as diarrhea, and reduces the risk of inflammatory bowel diseases in humans and mice. We previously demonstrated that a specific porcine NOD2 polymorphism (NOD2-2197A > C) augments the recognition of peptidoglycan components. In this study, the relationships between porcine NOD2-2197A/C genotypes affecting molecular functions and symptoms in a porcine circovirus 2b (PCV2b)-spreading Duroc pig population were investigated. The NOD2 allele (NOD2-2197A) with reduced recognition of the peptidoglycan components augmented the mortality of pigs at the growing stage in the PCV2b-spreading population. Comparison of NOD2 allele frequencies in the piglets before and after invasion of PCV2b indicated that the ratio of NOD2-2197A decreased in the population after the PCV2b epidemic. This data indicated that functional differences caused by NOD2-2197 polymorphisms have a marked impact on pig health and livestock productivity. We suggest that NOD2-2197CC is a PCV2 disease resistant polymorphism, which is useful for selective breeding by reducing mortality and increasing productivity. |
| Databáze: | OpenAIRE |
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