Stabilization of Delphinidin in Complex with Sulfobutylether-β-Cyclodextrin Allows for Antinociception in Inflammatory Pain

Autor:	Friedrich Schöppler, Jens Broscheit, Reine-Solange Sauer, Adel Ben-Kraiem, Ivo Krummenacher, Helga Stopper, Norbert Roewer, Shaobing Yang, Holger Braunschweig, Ulrike Holzgrabe, Milad Mohammadi, Beatrice Oehler, Heike L. Rittner, Ezgi Eylül Bankoglu, Alexander Brack, Paul Güntzel
Rok vydání:	2021
Předmět:	Male 0301 basic medicine Antioxidant Physiology medicine.medical_treatment Freund's Adjuvant Clinical Biochemistry Anti-Inflammatory Agents Sulfobutylether β cyclodextrin Pharmacology Biochemistry Anthocyanins 03 medical and health sciences chemistry.chemical_compound Drug Stability medicine Animals Humans Solubility TRPA1 Cation Channel Molecular Biology General Environmental Science Aldehydes 030102 biochemistry & molecular biology beta-Cyclodextrins food and beverages Cell Biology Inflammatory pain Rats Bioavailability Disease Models Animal HEK293 Cells 030104 developmental biology chemistry Hyperalgesia General Earth and Planetary Sciences Calcium Delphinidin
Zdroj:	Antioxidants & Redox Signaling. 34:1260-1279
ISSN:	1557-7716 1523-0864
DOI:	10.1089/ars.2019.7957
Popis:	Aims: Delphinidin (DEL) is a plant-derived antioxidant with clinical potential to treat inflammatory pain but suffers from poor solubility and low bioavailability. The aim of the study was to devel...
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3dd2cc689d9d592f50578dbef4eb5245 https://doi.org/10.1089/ars.2019.7957 Zobrazit plný text záznamu