Cytotoxic Effect of Alcohol on Liver Cells and Fibroblasts in Vitro
| Autor: | R. A. Fraser, W. Elmslie, F. Walker, G. C. M. Watt, P. E. Snape |
|---|---|
| Rok vydání: | 1974 |
| Předmět: |
Ethanol
Cell Survival business.industry Alcohol Trypan Blue General Medicine Fibroblasts 030204 cardiovascular system & hematology Pharmacology In vitro Cell Line Necrosis 03 medical and health sciences chemistry.chemical_compound 0302 clinical medicine Liver chemistry Humans Medicine Cytotoxic T cell Collagen 030212 general & internal medicine business Cells Cultured |
| Zdroj: | Scottish Medical Journal. 19:125-127 |
| ISSN: | 2045-6441 0036-9330 |
| DOI: | 10.1177/003693307401900305 |
| Popis: | Cultures of liver cells (Chang) and of fibroblasts (3T6) were exposed to media containing a range of concentrations of ethanol. At the end of a standard period of time the number of viable cells was determined. As the concentration of ethanol increased over 0.25 per cent v/v liver cell survival decreased progressively. Fibroblast survival decreased progressively at ethanol concentrations over 0.50 per cent v/v. This indicates that ethanol is more toxic to liver cells than to fibroblasts. Certain alcoholic beverages, particularly brandy, were found to be more toxic than pure ethanol. |
| Databáze: | OpenAIRE |
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