Habitual dietary intake of n-3 and n-6 fatty acids in relation to inflammatory markers among US men and women

Autor: Walter C. Willett, Gökhan S. Hotamisligil, Eric B. Rimm, Tobias Pischon, Nader Rifai, Susan E. Hankinson
Rok vydání: 2003
Předmět:
Male
Receptors
Tumor Necrosis Factor
Cohort Studies
Reference Values
Surveys and Questionnaires
Prospective Studies
Receptor
chemistry.chemical_classification
biology
Middle Aged
Eicosapentaenoic acid
C-Reactive Protein
Docosahexaenoic acid
Receptors
Tumor Necrosis Factor
Type I
Fatty Acids
Unsaturated
Tumor necrosis factor alpha
Female
medicine.symptom
Cardiology and Cardiovascular Medicine
Adult
medicine.medical_specialty
Diet therapy
Health Personnel
Inflammation
Sex Factors
Antigens
CD
Physiology (medical)
Internal medicine
Fatty Acids
Omega-6
Fatty Acids
Omega-3
medicine
Humans
Receptors
Tumor Necrosis Factor
Type II
Interleukin 6
Aged
business.industry
Interleukin-6
Fatty acid
Feeding Behavior
United States
Endocrinology
Cross-Sectional Studies
chemistry
biology.protein
Eicosanoids
business
Energy Intake
Biomarkers
Follow-Up Studies
Zdroj: Circulation. 108(2)
ISSN: 1524-4539
Popis: Background— Polyunsaturated fatty acid intake favorably affects chronic inflammatory-related diseases such as cardiovascular disease; however, high intake of n-6 fatty acids may attenuate the known beneficial effects of n-3 fatty acids. Methods and Results— We investigated habitual dietary n-3 fatty acid intake and its interaction with n-6 fatty acids in relation to the plasma inflammatory markers C-reactive protein, interleukin 6, and soluble tumor necrosis factor receptors 1 and 2 (sTNF-R1 and R2) among 405 healthy men and 454 healthy women. After adjustment for other predictors of inflammation, intake of the n-3 fatty acids eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA) was inversely associated with plasma levels of sTNF-R1 and sTNF-R2 ( P =0.03 and P P =0.08). n-3 α-linolenic acid and n-6 cis-linoleic acid were not significantly related to the inflammatory markers. We found little if any association between n-3 fatty acid (EPA+DHA) intake and tumor necrosis factor receptors among participants with low intake of n-6 but a strong inverse association among those with high n-6 intake ( P =0.04 and 0.002 for interaction of n-3 with n-6 on sTNF-R1 and sTNF-R2, respectively). Conclusions— These results suggest that n-6 fatty acids do not inhibit the antiinflammatory effects of n-3 fatty acids and that the combination of both types of fatty acids is associated with the lowest levels of inflammation. The inhibition of inflammatory cytokines may be one possible mechanism for the observed beneficial effects of these fatty acids on chronic inflammatory-related diseases.
Databáze: OpenAIRE
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