Serum Iron and Matrix Metalloproteinase-9 Variations in Limbs Affected by Chronic Venous Disease and Venous Leg Ulcers
| Autor: | Patrizia Fortini, Rea Legnaro, G. L. Scapoli, Donato Gemmati, Marcello Izzo, Silvia Tognazzo, Vincenzo Lanzara, Annunziata Palazzo, Paolo Zamboni |
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| Rok vydání: | 2006 |
| Předmět: |
Male
medicine.medical_specialty Pathology Iron Dermatology Matrix metalloproteinase Gastroenterology Lesion Internal medicine Humans Medicine Vascular Diseases chemistry.chemical_classification Haptoglobins biology medicine.diagnostic_test business.industry Vascular disease Macrophages Leg Ulcer Haptoglobin Transferrin General Medicine Middle Aged medicine.disease Ferritin Matrix Metalloproteinase 9 chemistry Hemosiderin Chronic Disease Ferritins biology.protein Serum iron Female Surgery medicine.symptom business |
| Zdroj: | Dermatologic Surgery. 31:644-649 |
| ISSN: | 1076-0512 |
| Popis: | BACKGROUND. Severe chronic venous disease (CVD) is characterized by both dermal hemosiderin accumulation and matrix metalloproteinase (MMP) hyperactivation. The iron-driven pathway is one of the recognized mechanisms of MMP hyperactivation. OBJECTIVE. To investigate the potential consequences of leg hemosiderin deposits on both iron metabolism and activation of MMPs. METHODS. We contemporaneously assessed the following in the serum of the arm and ankle veins of 30 patients (C4-6) with CVD and 14 normal subjects: ferritin, transferrin, iron, percentage of transferrin iron binding capacity (%TIBC), and MMP-9. Optical microscopy examinations with Perls' staining of chronic wounds were also performed. RESULTS. Histology consistently revealed iron deposits. Serum ferritin, iron, and %TIBC were significantly increased in the legs affected by severe CVD compared with the arm of the same subjects or the controls. In addition, iron and %TIBC were significantly elevated in the legs of ulcer patients. The rate of activation of MMP-9 was significantly elevated in CVD. CONCLUSIONS. The increased iron deposition in legs affected by CVD seems to be more instable in ulcer patients, leading to iron release in the serum of the affected leg. Our data suggest the iron-driven pathway as a further mechanism for MMP hyperexpression leading to tissue lesion. |
| Databáze: | OpenAIRE |
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