Transcriptional induction of two genes in human cells by beta interferon
| Autor: | Y S Cheng, G Jonak, E Knight, A C Larner, James E. Darnell, B Korant |
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| Rok vydání: | 1984 |
| Předmět: |
Transcription
Genetic DNA Recombinant RNA polymerase II Interferon-gamma Transcription (biology) Interferon medicine Protein biosynthesis Humans Interferon gamma RNA Messenger Multidisciplinary biology General transcription factor RNA Nucleic Acid Hybridization DNA Fibroblasts Molecular biology Protein Biosynthesis Interferon Type I biology.protein RNA Polymerase II Interferon type I medicine.drug HeLa Cells Research Article |
| Zdroj: | Proceedings of the National Academy of Sciences of the United States of America. 81(21) |
| ISSN: | 0027-8424 |
| Popis: | The binding of interferons to distinct cell surface receptors leads to the induction of synthesis of several unique polypeptides and their corresponding mRNAs (1-6). We have isolated two cDNAs that are complementary to nuclear RNA whose synthesis is induced from undetectable levels to maximal rates of transcription within 30-60 min after the addition of beta interferon to human fibroblasts or to HeLa cells. These results prove that a single polypeptide can, by binding to a specific plasma membrane receptor, promptly activate the transcription of a defined set of genes. |
| Databáze: | OpenAIRE |
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