Enantioselective Coupling of Dienes and Phosphine Oxides
| Autor: | Ryan T Davison, Shao-Zhen Nie, Vy M. Dong |
|---|---|
| Rok vydání: | 2018 |
| Předmět: |
Allylic rearrangement
Phosphines Stereoisomerism Chemistry Techniques Synthetic 010402 general chemistry 01 natural sciences Biochemistry Article Catalysis chemistry.chemical_compound Colloid and Surface Chemistry Coordination Complexes Organic chemistry 010405 organic chemistry Extramural Intermolecular force Enantioselective synthesis General Chemistry 0104 chemical sciences Alkadienes Allyl Compounds chemistry Palladium Phosphine |
| Zdroj: | Journal of the American Chemical Society. 140:16450-16454 |
| ISSN: | 1520-5126 0002-7863 |
| Popis: | We report a Pd-catalyzed intermolecular hydrophosphinylation of 1,3-dienes to afford chiral allylic phosphine oxides. Commodity dienes and air stable phosphine oxides couple to generate organophosphorus building blocks with high enantio- and regiocontrol. This method constitutes the first asymmetric hydrophosphinylation of dienes. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|