Mathematical Models of the Impact of IL2 Modulation Therapies on T Cell Dynamics
| Autor: | Karina García-Martínez, Tania Carmenate, Kalet León |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2013 |
| Předmět: |
lcsh:Immunologic diseases. Allergy
musculoskeletal diseases Computer science T cell Population Immunology Future application Context (language use) chemical and pharmacologic phenomena Review Article Bioinformatics interleukin 2 regulatory T cells immune system diseases medicine Immunology and Allergy education education.field_of_study Mathematical model T cell dynamics hemic and immune systems interleukin 2 mutants stomatognathic diseases medicine.anatomical_structure lcsh:RC581-607 Memory T cell Neuroscience mathematical model |
| Zdroj: | Frontiers in Immunology Frontiers in Immunology, Vol 4 (2013) |
| ISSN: | 1664-3224 |
| Popis: | Several reports in the literature have drawn a complex picture of the effect of treatments aiming to modulate IL2 activity in vivo. They seem to promote either immunity or tolerance, probably depending on the specific context, dose, and timing of their application. Such complexity might derive from the pleiotropic role of IL2 in T cell dynamics. To theoretically address the latter possibility, our group has developed several mathematical models for Helper, Regulatory, and Memory T cell population dynamics, which account for most well-known facts concerning their relationship with IL2. We have simulated the effect of several types of therapies, including the injection of: IL2; antibodies anti-IL2; IL2/anti-IL2 immune-complexes; and mutant variants of IL2. We studied the qualitative and quantitative conditions of dose and timing for these treatments which allow them to potentiate either immunity or tolerance. Our results provide reasonable explanations for the existent pre-clinical and clinical data, predict some novel treatments, and further provide interesting practical guidelines to optimize the future application of these types of treatments. |
| Databáze: | OpenAIRE |
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