Fejerlectin, a Lectin-like Peptide from the Skin of Fejervarya limnocharis, Inhibits HIV‑1 Entry by Targeting Gp41
| Autor: | Yi-Bin Li, Chenliang Zhou, Lin Li, Weichen Xiong, Shuwen Yin, Jinwei Chai, Xueqing Xu, Baishuang Zeng, Jiena Wu |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2021 |
| Předmět: |
chemistry.chemical_classification
biology Hemagglutination General Chemical Engineering virus diseases Lectin Lipid bilayer fusion Peptide General Chemistry biology.organism_classification Gp41 Virology Microbicides for sexually transmitted diseases Heptad repeat Chemistry Fejervarya limnocharis chemistry biology.protein QD1-999 |
| Zdroj: | ACS Omega, Vol 6, Iss 9, Pp 6414-6423 (2021) |
| ISSN: | 2470-1343 |
| Popis: | Human immunodeficiency virus type 1 (HIV-1) is mainly transmitted by sexual intercourse, and effective microbicides preventing HIV-1 transmission are still required. Amphibian skin is a rich source of defense peptides with antiviral activity. Here, we characterized a lectin-like peptide, fejerlectin (RLCYMVLPCP), isolated from the skin of the frog Fejervarya limnocharis. Fejerlectin showed significant hemagglutination and d-(+)-galacturonic acid-binding activities. Furthermore, fejerlectin suppressed the early entry of HIV-1 into target cells by binding to the N-terminal heptad repeat of HIV-1 gp41 and preventing 6-HB formation and Env-mediated membrane fusion. Fejerlectin is the smallest lectin-like peptide identified to date and represents a new and promising platform for anti-HIV-1 drug development. |
| Databáze: | OpenAIRE |
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