Intracortical excitatory and inhibitory phenomena to paired transcranial magnetic stimulation in healthy human subjects: differences between the right and left hemisphere
| Autor: | Patrizio Pasqualetti, Maria Giuseppina Palmieri, Massimiliano Oliveri, Paola Cicinelli, Paolo Maria Rossini, R. Traversa, Maria Maddalena Filippi |
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| Rok vydání: | 2000 |
| Předmět: |
Cerebral Cortex
General Neuroscience medicine.medical_treatment Excitatory Postsynaptic Potentials Neural Inhibition Neurophysiology Evoked Potentials Motor Inhibitory postsynaptic potential Synaptic Transmission humanities Lateralization of brain function Transcranial magnetic stimulation Electrophysiology medicine.anatomical_structure Cerebral cortex Excitatory postsynaptic potential medicine Humans Psychology Electromagnetic Phenomena human activities Neuroscience Motor cortex |
| Zdroj: | Neuroscience Letters. 288:171-174 |
| ISSN: | 0304-3940 |
| DOI: | 10.1016/s0304-3940(00)01216-7 |
| Popis: | Intracortical inhibition (ICI) and facilitation (ICF) to paired magnetic stimuli reflect the activation of interneuronal circuits within the motor cortex. Intersubjects physiological variability of these phenomena, partly limits the usefulness of such method. Therefore, interhemispheric ICI/ICF differences might represent a more sensitive and less variable neurophysiological parameter to test the motor cortex excitability. Motor evoked potentials from the hand muscles were recorded in ten healthy subjects in a paired-pulse paradigm. Interstimulus intervals (ISIs) from 1 to 50 ms were used. The time course of ICI and ICF in the two hemispheres is consistent with minimal interhemispheric asymmetries. The interhemispheric differences of ICI and ICF could be a valuable neurophysiological marker for the diagnosis, prognosis and follow-up of neurological diseases characterized by monohemispheric damage and lateralized motor deficits. |
| Databáze: | OpenAIRE |
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