Novelty-Induced Phase-Locked Firing to Slow Gamma Oscillations in the Hippocampus: Requirement of Synaptic Plasticity
| Autor: | Sakiko Ujita, Ayumu Tashiro, Takuma Kitanishi, Naomi Kitanishi, Yuji Ikegaya, Mehdi Fallahnezhad |
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| Přispěvatelé: | School of Biological Sciences |
| Rok vydání: | 2015 |
| Předmět: |
Science::Biological sciences::Human anatomy and physiology::Neurobiology [DRNTU]
Male Neuronal Plasticity Neuroscience(all) musculoskeletal neural and ocular physiology General Neuroscience Neuronal firing Novelty Phase (waves) Action Potentials Hippocampus AMPA receptor Hippocampal formation Biology Phase locking Rats nervous system Synapses Synaptic plasticity Exploratory Behavior Animals Gamma Rhythm Rats Long-Evans Neuroscience |
| Zdroj: | Neuron. 86:1265-1276 |
| ISSN: | 0896-6273 |
| DOI: | 10.1016/j.neuron.2015.05.012 |
| Popis: | Temporally precise neuronal firing phase-locked to gamma oscillations is thought to mediate the dynamic interaction of neuronal populations, which is essential for information processing underlying higher-order functions such as learning and memory. However, the cellular mechanisms determining phase locking remain unclear. By devising a virus-mediated approach to perform multi-tetrode recording from genetically manipulated neurons, we demonstrated that synaptic plasticity dependent on the GluR1 subunit of AMPA (α-amino-3-hydroxy-5-methyl-4-isoxazole propionate) receptor mediates two dynamic changes in neuronal firing in the hippocampal CA1 area during novel experiences: the establishment of phase-locked firing to slow gamma oscillations and the rapid formation of the spatial firing pattern of place cells. The results suggest a series of events potentially underlying the acquisition of new spatial information: slow gamma oscillations, originating from the CA3 area, induce the two GluR1-dependent changes of CA1 neuronal firing, which in turn determine information flow in the hippocampal-entorhinal system. Accepted version |
| Databáze: | OpenAIRE |
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