Tissue Acquisition During EBUS-TBNA
Autor: | Avelino C. Verceles, Jonathon Heath, Ashutosh Sachdeva, Edward M. Pickering, Or Kalchiem-Dekel, Van K. Holden |
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Rok vydání: | 2019 |
Předmět: |
Image-Guided Biopsy
Male Pulmonary and Respiratory Medicine Ebus tbna Lung Neoplasms Lymphoma Sarcoidosis Adenocarcinoma Mediastinal Neoplasms Endosonography Lesion 03 medical and health sciences 0302 clinical medicine Bronchoscopy Carcinoma Non-Small-Cell Lung Biopsy Carcinoma medicine Humans Prospective Studies 030212 general & internal medicine Prospective cohort study Cell block Aged medicine.diagnostic_test business.industry Biopsy Needle Middle Aged medicine.disease Small Cell Lung Carcinoma Tissue acquisition 030228 respiratory system Carcinoma Squamous Cell Carcinoma Large Cell Female Lymph Nodes medicine.symptom Nuclear medicine business |
Zdroj: | Journal of Bronchology & Interventional Pulmonology. 26:237-244 |
ISSN: | 1944-6586 |
Popis: | Background Previous studies have shown that needle gauge size has no significant impact on diagnostic yield during endobronchial ultrasound-guided transbronchial needle aspiration (EBUS-TBNA). Our objective was to determine whether cell blocks obtained via the new Flex 19G EBUS-TBNA needle would contain more cellular material based on cell area compared with those obtained from a 21G needle. Methods A prospective analysis of patients undergoing EBUS-TBNA at our institutions was performed. Sampling of the same lesion(s) with both the Flex 19G and 21G needles was performed in an alternating manner. In total, 47 patients with suspected lung cancer or mediastinal/hilar lymphadenopathy were included with a total of 83 lesions biopsied. Cell block area was calculated using the Aperio ImageScope software. Results Mean cell area in the Flex 19G group was 7.34±12.46 mm compared with 5.23±10.73 mm in the 21G group (P=0.02). In the malignant subgroup, the average cell area was 16.16±16.30 mm in the Flex 19G group versus 11.09±15.55 mm in the 21G group (P=0.02). No significant difference was noted in the mean cell area within the nonmalignant subgroup, 1.80±3.01 mm in the 19G group versus 1.56±1.79 mm in the 21G group (P=0.60). Conclusion The cell area obtained via the 19G needle was significantly larger than that obtained with the 21G needle. Further multicenter randomized studies are needed to identify the utility of the Flex 19G needle in diagnosing/subtyping lymphoproliferative disorders and adequacy for molecular testing in non-small cell lung cancer. |
Databáze: | OpenAIRE |
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