Prodrug‐Loaded Zirconium Carbide Nanosheets as a Novel Biophotonic Nanoplatform for Effective Treatment of Cancer
| Autor: | Taojian Fan, Inseob Shim, Bo Ding, Dou Wang, Zhongjian Xie, Yan Qiaoting, Han Zhang, Chaoying Wei, Quan Liu, Yunlong Yang, Sisi Xie, Meng Qiu, Zongze Wu, Xinhuang Yao, Hongzhong Wang, Jong Seung Kim, Hong Wu, Yihai Cao, Hyeong Seok Kim, Shiyou Chen, Zhen Cai, Qingshuang Zou, Ziheng Guo, Yuhua Zhang, Qinhe Yang, Dickson Adah, Liping Liu |
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| Rok vydání: | 2020 |
| Předmět: |
photothermal therapy
Angiogenesis General Chemical Engineering medicine.medical_treatment General Physics and Astronomy Medicine (miscellaneous) 02 engineering and technology chemotherapy 010402 general chemistry 01 natural sciences Biochemistry Genetics and Molecular Biology (miscellaneous) Metastasis angiogenesis In vivo medicine General Materials Science Chemotherapy Chemistry Communication General Engineering Cancer Photothermal therapy Prodrug 021001 nanoscience & nanotechnology medicine.disease Communications 0104 chemical sciences zirconium carbide Cancer research Nanomedicine prodrug 0210 nano-technology |
| Zdroj: | Advanced Science |
| ISSN: | 2198-3844 |
| DOI: | 10.1002/advs.202001191 |
| Popis: | Conventional chemotherapy and photothermal therapy (PTT) face many major challenges, including systemic toxicity, low bioavailability, ineffective tissue penetration, chemotherapy/hyperthermia‐induced inflammation, and tumor angiogenesis. A versatile nanomedicine offers an exciting opportunity to circumvent the abovementioned limitations for their successful translation into clinical practice. Here, a promising biophotonic nanoplatform is developed based on the zirconium carbide (ZrC) nanosheet as a deep PTT‐photosensitizer and on‐demand designed anticancer prodrug SN38‐Nif, which is released and activated by photothermia and tumor‐overexpressed esterase. In vitro and in vivo experimental evidence shows the potent anticancer effects of the integrated ZrC@prodrug biophotonic nanoplatform by specifically targeting malignant cells, chemotherapy/hyperthermia‐induced tumor inflammation, and angiogenesis. In mouse models, the ZrC@prodrug system markedly inhibits tumor recurrence, metastasis, inflammation and angiogenesis. The findings unravel a promising biophotonic strategy for precision treatment of cancer. A biophotonic nanoplatform based on the zirconium carbide (ZrC) nanosheet as a deep photothermal therapy‐photosensitizer and on‐demand designed anticancer prodrug SN38‐Nif is developed. Both physically controlled and bioresponsive mode are employed to smartly release drugs. The ZrC@prodrug system markedly inhibits tumor recurrence, metastasis, inflammation, and angiogenesis. The findings unravel a promising biophotonic strategy for precision treatment of cancer. |
| Databáze: | OpenAIRE |
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