Marathon running transiently depletes the myocardial lipid pool

Autor: Gustav J. Strijkers, Jithsa R. Monte, Sandra van den Berg-Faay, Aart J. Nederveen, Adrianus J. Bakermans, Thijs M. H. Eijsvogels, Vincent L. Aengevaeren, Martijn Froeling, Melissa T. Hooijmans
Přispěvatelé: Biomedical Engineering and Physics, Graduate School, ACS - Diabetes & metabolism, Amsterdam Neuroscience - Brain Imaging, Amsterdam Gastroenterology Endocrinology Metabolism, Amsterdam Movement Sciences, ACS - Atherosclerosis & ischemic syndromes, ACS - Heart failure & arrhythmias, Radiology and Nuclear Medicine, AMS - Sports
Jazyk: angličtina
Rok vydání: 2020
Předmět:
Zdroj: Physiological reports, 8(17):e14543. John Wiley and Sons Inc.
Physiological Reports
Physiological Reports, Vol 8, Iss 17, Pp n/a-n/a (2020)
Physiological Reports, 8
Physiological Reports, 8, 17
ISSN: 2051-817X
Popis: Lipids, stored as intracellular triacylglycerol droplets within the myocardium, serve as an important source of energy, particularly in times of prolonged increased energy expenditure. In only a few studies, the acute effects of exercise on such ectopic myocardial lipid storage were investigated. We studied the dynamic behavior of the myocardial lipid pool in response to completing the 2017 Amsterdam Marathon using proton magnetic resonance (MR) spectroscopy (1H‐MRS). We hypothesized that the prolonged increased myocardial energy demand of running a marathon could shift the balance of myocardial triacylglycerol turnover from triacylglycerol synthesis toward lipolysis and mitochondrial fatty acid β‐oxidation, and decrease the myocardial lipid pool. We employed two 3 Tesla MR systems in parallel to noninvasively examine endurance‐trained healthy men (n = 8; age 50.7 [50.1–52.7] y) at 1 week prior (baseline)
The acute effects of exercise on ectopic myocardial lipid storage have not been investigated in a real‐life endurance exercise scenario. We studied the dynamic behavior of the myocardial lipid pool in response to marathon running with proton MR spectroscopy. Using two MR systems in parallel, we examined eight endurance‐trained men within 6 hr of completing a marathon, and compared results with baseline and recovery measurements. Our data demonstrate a transient high‐intensity exercise‐induced depletion of the myocardial lipid pool.
Databáze: OpenAIRE
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