Structure-specific antitumor effects and potential gut microbiota-involved mechanisms of ginseng polysaccharides on B16F10 melanoma-bearing mice
| Autor: | Ni-Na Xie, Cheng-Ying Wu, Qiong Ge, Jing Zhou, Fang Long, Qian Mao, Song-Lin Li, Hong Shen |
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| Rok vydání: | 2023 |
| Předmět: | |
| Zdroj: | Food & Function. 14:796-809 |
| ISSN: | 2042-650X 2042-6496 |
| DOI: | 10.1039/d2fo03383f |
| Popis: | Ginseng polysaccharides (GPs) have shown gut microbiota-related antitumor effects. However, the relation between their structures and antitumor functions remains unknown. Here, crude polysaccharide (GP-c) and its fractions neutral polysaccharide (GP-n) and pectin (GP-a) were prepared for structure characterization and anti-B16F10 melanoma effect evaluation, and their influence on gut microbiota diversities and short-chain fatty acids (SCFAs) were also analyzed. Spearman correlations among the altered gut microbiota, SCFAs, and antitumor effects were conducted to elucidate the structure-function relationships. It was shown that the structures of GP-c, GP-n, and GP-a varied in monosaccharide composition and molecular weight distribution. GP-n and GP-c showed anti-melanoma effects, whereas GP-a promoted its growth slightly. GP-n and GP-c restored SCFAs levels such as acetic acid and butyric acid; moreover, it improved the gut microbiota ecosystem by upregulating the abundance of |
| Databáze: | OpenAIRE |
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