Posatirelin in the treatment of vascular dementia: a double-blind multicentre study vs placebo
| Autor: | A. Poli, Lodovico Frattola, N. Martucci, P. Caratozzolo, L. Ambrosoli, G. Nappi, L Fossati, R. Girardello, G. Agliati, Luigi Murri, F. M. Puca, Lucilla Parnetti, U. Senin |
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| Rok vydání: | 2009 |
| Předmět: |
Male
medicine.medical_specialty Placebo Central nervous system disease Drug withdrawal Double-Blind Method analogs /&/ derivatives/therapeutic use Rating scale Vascular Internal medicine medicine Humans Dementia Vascular dementia Thyrotropin-Releasing Hormone Aged Psychiatric Status Rating Scales Dementia Vascular Aged Dementia drug therapy/psychology Double-Blind Method Female Humans Male Middle Aged Psychiatric Status Rating Scales Thyrotropin-Releasing Hormone General Medicine Middle Aged medicine.disease Surgery Neurology Tolerability drug therapy/psychology Female Neurology (clinical) Analysis of variance Psychology |
| Zdroj: | Acta Neurologica Scandinavica. 93:456-463 |
| ISSN: | 1600-0404 0001-6314 |
| DOI: | 10.1111/j.1600-0404.1996.tb00026.x |
| Popis: | Introduction - The usefulness of posatirelin (L-pyro-2-aminoadipyl-L-leucyl-L-prolinamide), a synthetic peptide having modulatory activity on the monoaminergic and cholinergic systems and neurotrophic effects, was evaluated in vascular dementia. Patients and methods - A multicentre, parallel groups, double-blind clinical study vs placebo was carried out with patients suffering from probable vascular dementia according to the NINDS-AIREN criteria. The study consisted of a two-week run-in of a once daily, orally administered, placebo phase, followed by 12 weeks of intramuscular treatment with posatirelin 10 mg/ml or placebo given once a day and a follow-up after one month's withdrawal. Efficacy was assessed using the Gottfries-Brane-Steen (GBS) Rating Scale for dementia, the Randt Memory Test and the Toulouse-Pieron Attention Test. Data were evaluated using analysis of variance and covariance. Results - As regards GBS scores, patients treated with posatirelin showed a significant improvement in intellectual performance, in orientation, motivation and memory as compared to controls. The improvement of memory performance was also confirmed by the acquisition score and memory index of the Randt Memory Test. At the end of the follow-up period the differences between treatments were still maintained. Tolerability was good. Conclusions - The significant improvement observed in cognitive functions, attention and motivation of demented patients treated with posatirelin suggests the potential usefulness of this drug in vascular dementia. Furthermore, the presence of a long-lasting effect after drug withdrawal suggests the possibility of administering the drug cyclically. |
| Databáze: | OpenAIRE |
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