Impact of post-implant dosimetric parameters on the quality of life of patients treated with low-dose rate brachytherapy for localised prostate cancer: results of a single-institution study
| Autor: | Luigi Tomio, Francesca Maines, Francesco Ziglio, Salvatore Mussari, Antonello Veccia, Orazio Caffo, G. Fellin, Enzo Galligioni |
|---|---|
| Rok vydání: | 2015 |
| Předmět: |
Quality of life
Male Organs at Risk Oncology medicine.medical_specialty Urinary system medicine.medical_treatment Brachytherapy Urinary Bladder Urology Rectum Adenocarcinoma Genitalia Male Prostate cancer Urethra Dosimetry Surveys and Questionnaires Internal medicine Activities of Daily Living medicine Humans Interpersonal Relations Radiology Nuclear Medicine and imaging Prospective Studies Prospective cohort study Aged business.industry Research Radiotherapy Planning Computer-Assisted Prostatic Neoplasms Urination disorder Radiotherapy Dosage Middle Aged Urination Disorders medicine.disease Intestinal Diseases Sexual Dysfunction Physiological medicine.anatomical_structure Radiology Nuclear Medicine and imaging business Follow-Up Studies |
| Zdroj: | Radiation Oncology (London, England) |
| ISSN: | 1748-717X |
| DOI: | 10.1186/s13014-015-0434-4 |
| Popis: | Background To assess the relationship between dosimetric parameters and the quality of life (QL) outcomes of patients with low-intermediate-risk localised prostate cancer (LPC) treated with low-dose-rate brachytherapy (LDR-BT). Materials and methods We evaluated the participants in two consecutive prospective studies of the QL of patients treated with LDR-BT for LPC. QL was evaluated by means of a patient-completed questionnaire assessing non functional [physical (PHY) and psychological (PSY) well-being, physical autonomy (POW), social relationships (REL)] and functional scales [urinary (URI), rectal (REC), and sexual (SEX) function]; a scale for erectile function (ERE) was included in the second study. Urethra (D10 ≤ 210 Gy) and rectal wall constraints (V100 ≤ 0.5 cc) were used for pre-planning dosimetry and were assessed with post planning computerized tomography one month later for each patient. Results QL was assessed in 251 LPC patients. Dosimetry did not influence the non-functional scales. As expected, a progressive impairment in sexual and erectile function was reported one month after LDR-BT, and became statistically significant after the third year. Rectal function significantly worsened after LDR-BT, but the differences progressively decreased after the 1-year assessment. Overall urinary function significantly worsened immediately after LDR-BT and then gradually improved over the next three years. Better outcomes were reported for V100 rectal wall volumes of ≤ 0.5 cc and D10 urethra values of ≤ 210 Gy. Conclusions The findings of this study show that dosimetric parameters influence only functional QL outcomes while non-functional outcomes are only marginally influenced. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|
Full text from SpringerLink