Stroke-related alterations in inter-areal communication
| Autor: | Michele Allegra, Nicholas V. Metcalf, Maurizio Corbetta, Chiara Favaretto, Andrea Brovelli |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2021 |
| Předmět: |
Stroke patient
RSNs resting-state networks Cognitive Neuroscience Computer applications to medicine. Medical informatics R858-859.7 Ischemia FC functional connectivity 03 medical and health sciences Granger causality Resting state fMRI Stroke 0302 clinical medicine medicine IC instantaneous (Granger) causality Humans Radiology Nuclear Medicine and imaging cardiovascular diseases RC346-429 LH/RH left/right hemisphere 030304 developmental biology 0303 health sciences Brain Mapping Granger causality analysis business.industry Functional connectivity GC Granger causality Communication UFC undirected functional connectivity Brain Cognition Regular Article medicine.disease Functional recovery Magnetic Resonance Imaging Neurology fMRI functional magnetic resonance imaging DC directed (Granger) causality Neurology. Diseases of the nervous system Neurology (clinical) Functional organization business Neuroscience 030217 neurology & neurosurgery |
| Zdroj: | NeuroImage : Clinical NeuroImage: Clinical, Vol 32, Iss, Pp 102812-(2021) |
| ISSN: | 2213-1582 |
| Popis: | Highlights • We used covariance-based Granger Causality on resting-state fMRI of stroke patients. • Stroke determines an overall decrease of homotopic Granger causality (GC) • Stroke determines a decrease of GC from and within the lesioned hemisphere. • Stroke causes imbalances in GC between the lesioned and the healthy hemisphere. • GC anomalies correlate with impaired performance in several behavioral domains. Beyond causing local ischemia and cell damage at the site of injury, stroke strongly affects long-range anatomical connections, perturbing the functional organization of brain networks. Several studies reported functional connectivity abnormalities parallelling both behavioral deficits and functional recovery across different cognitive domains. FC alterations suggest that long-range communication in the brain is altered after stroke. However, standard FC analyses cannot reveal the directionality and time scale of inter-areal information transfer. We used resting-state fMRI and covariance-based Granger causality analysis to quantify network-level information transfer and its alteration in stroke. Two main large-scale anomalies were observed in stroke patients. First, inter-hemispheric information transfer was significantly decreased with respect to healthy controls. Second, stroke caused inter-hemispheric asymmetries, as information transfer within the affected hemisphere and from the affected to the intact hemisphere was significantly reduced. Both anomalies were more prominent in resting-state networks related to attention and language, and they correlated with impaired performance in several behavioral domains. Overall, our findings support the hypothesis that stroke provokes asymmetries between the affected and spared hemisphere, with different functional consequences depending on which hemisphere is lesioned. |
| Databáze: | OpenAIRE |
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