Virology and cell biology of the hepatitis C virus life cycle – An update

Autor: Jean Dubuisson, François-Loïc Cosset
Přispěvatelé: Centre d’Infection et d’Immunité de Lille - INSERM U 1019 - UMR 9017 - UMR 8204 (CIIL), Institut Pasteur de Lille, Réseau International des Instituts Pasteur (RIIP)-Réseau International des Instituts Pasteur (RIIP)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Lille-Centre Hospitalier Régional Universitaire [Lille] (CHRU Lille)-Centre National de la Recherche Scientifique (CNRS), Virus enveloppés, vecteurs et immunothérapie – Enveloped viruses, Vectors and Immuno-therapy (EVIR), Centre International de Recherche en Infectiologie (CIRI), École normale supérieure de Lyon (ENS de Lyon)-Université Claude Bernard Lyon 1 (UCBL), Université de Lyon-Université de Lyon-Université Jean Monnet - Saint-Étienne (UJM)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS)-École normale supérieure de Lyon (ENS de Lyon)-Université Claude Bernard Lyon 1 (UCBL), Université de Lyon-Université de Lyon-Université Jean Monnet - Saint-Étienne (UJM)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS), LabEx ECOFECT Inserm U1111, Work in the JD laboratory was supported by the French National Agency for Research on AIDS and Viral Hepatitis (ANRS) and ANR through ERA-NET Infect-ERA program (ANR-13-IFEC-0002-01). Work in the FLC laboratory was supported by ANRS, the European Research Council (ERC-2008-AdG-233130-HEPCENT) and the LabEx ECOFECT (ANR-11-LABX-0048) of Université de Lyon., We thank Laurence Cocquerel and Marlène Dreux for critical reading of the manuscript and Sophana Ung for help with the Figures. We apologize to all colleagues whose work could not be referenced because of length restriction., Centre National de la Recherche Scientifique (CNRS)-Centre Hospitalier Régional Universitaire [Lille] (CHRU Lille)-Université de Lille-Institut National de la Santé et de la Recherche Médicale (INSERM)-Institut Pasteur de Lille, Réseau International des Instituts Pasteur (RIIP)-Réseau International des Instituts Pasteur (RIIP), Centre International de Recherche en Infectiologie - UMR (CIRI), École normale supérieure - Lyon (ENS Lyon)-Université Claude Bernard Lyon 1 (UCBL), Université de Lyon-Université de Lyon-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS)-École normale supérieure - Lyon (ENS Lyon)-Université Claude Bernard Lyon 1 (UCBL), Université de Lyon-Université de Lyon-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS)
Rok vydání: 2014
Předmět:
Cirrhosis
MESH: Virus Replication/physiology
[SDV]Life Sciences [q-bio]
Hepacivirus
medicine.disease_cause
Virus Replication
MESH: Hepacivirus/growth & development
Virus entry
MESH: RNA
Viral/physiology
MESH: Hepatitis C/pathology
MESH: Cell Biology/trends
education.field_of_study
MESH: Life Cycle Stages/physiology
Hepatitis C virus
Viral life cycle
MESH: Hepacivirus/pathogenicity
virus diseases
MESH: Hepatitis C/physiopathology
Hepatitis C
3. Good health
Interaction with host
Hepatocellular carcinoma
MESH: Hepacivirus/genetics
[SDV.MP.VIR]Life Sciences [q-bio]/Microbiology and Parasitology/Virology
RNA
Viral
MESH: Virology/trends
Population
Biology
Virus-host interactions
MESH: Lipid Metabolism/physiology
Virology
medicine
Humans
education
Hepatitis
Life Cycle Stages
MESH: Humans
Hepatology
Cell Biology
medicine.disease
Lipid Metabolism
digestive system diseases
MESH: Hepatocytes/pathology
MESH: Hepatocytes/virology
Immunology
Hepatocytes
[SDV.MHEP]Life Sciences [q-bio]/Human health and pathology
Zdroj: Journal of Hepatology
Journal of Hepatology, 2014, Journal of Hepatology Update: Hepatitis C, 61 (1 Suppl), pp.S3-S13. ⟨10.1016/j.jhep.2014.06.031⟩
Journal of Hepatology, Elsevier, 2014, Journal of Hepatology Update: Hepatitis C, 61 (1 Suppl), pp.S3-S13. ⟨10.1016/j.jhep.2014.06.031⟩
ISSN: 0168-8278
1600-0641
DOI: 10.1016/j.jhep.2014.06.031
Popis: Affiliations ECOFECT; International audience; Hepatitis C virus (HCV) is an important human pathogen that causes hepatitis, liver cirrhosis and hepatocellular carcinoma. It imposes a serious problem to public health in the world as the population of chronically infected HCV patients who are at risk of progressive liver disease is projected to increase significantly in the next decades. However, the arrival of new antiviral molecules is progressively changing the landscape of hepatitis C treatment. The search for new anti-HCV therapies has also been a driving force to better understand how HCV interacts with its host, and major progresses have been made on the various steps of the HCV life cycle. Here, we review the most recent advances in the fast growing knowledge on HCV life cycle and interaction with host factors and pathways.
Databáze: OpenAIRE
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