Persistent Helicobacter pylori infection for more than 3 years leads to elevated serum homocysteine concentration: A retrospective cohort study based on a healthy Chinese population
| Autor: | Jinshun Zhang, Zhongtai Wang, Weiling Chen, Yahong Chen, Hongfang Xu, Chunli Xu, Huihong Wang |
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| Rok vydání: | 2021 |
| Předmět: |
Adult
Male China medicine.medical_specialty Helicobacter pylori infection Adolescent Homocysteine New infection Gastroenterology Helicobacter Infections Elevated serum Young Adult chemistry.chemical_compound Internal medicine medicine Humans Aged Retrospective Studies Breath test Chinese population Helicobacter pylori Hepatology biology medicine.diagnostic_test business.industry Retrospective cohort study Middle Aged biology.organism_classification Breath Tests chemistry Case-Control Studies Female Persistent Infection business |
| Zdroj: | Journal of Gastroenterology and Hepatology. 36:3077-3083 |
| ISSN: | 1440-1746 0815-9319 |
| Popis: | Background and aim The relationship between the Helicobacter pylori (H. pylori) infection and homocysteine is unclear. We evaluated the effect of H. pylori on serum homocysteine in a healthy Chinese population. Methods A total of 21,184 individuals aged over 18 years underwent 13 C/14 C urease breath test (13 C/14 C-UBT) and blood tests, and 5042 individuals with follow-up intervals greater than 6 months. Homocysteine levels are classified according to the Chinese expert consensus. Results The rates of H. pylori infection of normal level, mild level, moderate level, and severe level were 40.9%, 43.8%, 45.8% and 46.6% respectively (P = 0.000). H. pylori infection increased the risk of higher homocysteine concentration (OR = 1.406, P = 0.000). In the case-control study, the rates of persistent negative, new infection, persistent infection, and eradication infection was 43.6%, 11.2%, 22.9% and 22.3% respectively. The percentage of changes in serum homocysteine levels varied significantly among the different H. pylori infection statuses only in mild level (P = 0.024). Mean changed homocysteine values were higher in the subgroup of persistent infection than in the persistent negative subgroup (P = 0.004) and the eradication infection subgroup (P = 0.034). Serum homocysteine values were elevated only in the subgroup with over three years' interval time and persistent infection (n = 107, mean paired differences = 1.1±4.6 umol/L, P = 0.014). Conclusions There is a relationship between H. pylori and serum homocysteine, and persistent infection leads to elevation of the latter. |
| Databáze: | OpenAIRE |
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