Contribution of intraganglionic CGRP to migraine-like responses in male and female rats
| Autor: | Amanda Ribeiro Barroso, Erika Ivanna Araya, Joelle de Melo Turnes, Juliana Geremias Chichorro |
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| Rok vydání: | 2019 |
| Předmět: |
Male
medicine.medical_specialty Calcitonin Gene-Related Peptide Migraine Disorders Peptide Calcitonin gene-related peptide Mechanical Allodynia 03 medical and health sciences Trigeminal ganglion 0302 clinical medicine Internal medicine Animals Medicine Rats Wistar 030304 developmental biology chemistry.chemical_classification Sex Characteristics 0303 health sciences Sumatriptan business.industry General Medicine Serotonin 5-HT1 Receptor Agonists medicine.disease Rats Endocrinology Trigeminal Ganglion chemistry Migraine Hyperalgesia Calcitonin Female Neurology (clinical) business 030217 neurology & neurosurgery |
| Zdroj: | Cephalalgia. 40:689-700 |
| ISSN: | 1468-2982 0333-1024 |
| Popis: | Objective To evaluate whether intraganglionic calcitonin gene-related peptide induced differential migraine-like responses in male and female rats. Methods Calcitonin gene-related peptide was injected in the trigeminal ganglion of male and female rats followed by assessment of periorbital mechanical allodynia with von Frey hairs. The influence of systemic treatment with sumatriptan or intraganglionic treatment with minocycline and propentofylline was determined on the calcitonin gene-related peptide-induced mechanical allodynia in male and female rats. One additional group was exposed to an aversive light 24 h after calcitonin gene-related peptide priming, followed by evaluation of periorbital mechanical threshold, and another group was tested in the elevated-plus maze. Results Intraganglionar calcitonin gene-related peptide-induced periorbital mechanical allodynia in female (0.5 to 6 h) and male rats (0.5 to 4 h). Systemic sumatriptan briefly attenuated the mechanical allodynia, but intraganglionar minocycline or propentofylline injection was effective only in male rats. Calcitonin gene-related peptide induced photic sensitivity in female and male rats (lasting 4 h and 1 h, respectively), as well as anxiety-like behavior. Conclusions Intraganglionar calcitonin gene-related peptide may play a major role in migraine-like responses, including periorbital mechanical allodynia, light sensitivity and anxiety like-behavior. Female rats are likely to be more susceptible to calcitonin gene-related peptide effects and a better understanding of the sexual dimorphism in calcitonin gene-related peptide signaling may help to improve migraine therapy. |
| Databáze: | OpenAIRE |
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